P-cadherin expression in glandular lesions of the uterine cervix detected by li...

• Autor(es): Longatto Filho, Adhemar ; Albergaria, André ; Paredes, Joana ; Moreira, M. A. R. ; Milanezi, Fernanda ; Schmitt, Fernando C.
• Data: 2005
• Identificador Persistente: http://hdl.handle.net/1822/2933
• Origem: RepositóriUM - Universidade do Minho
• Assunto(s): P-cadherin; Uterine cervix; Glandular lesions; Liquid-based cytology
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

Objective: To study P-cadherin aberrant expression as a possible marker for cervical adenocarcinomas in cytological samples. Methods: We studied P-cadherin immunoexpression in liquid-based cervical cytology samples of biopsy-proven cervical lesions. Results: We found a statistically significant correlation between P-cadherin expression and a cytological diagnosis of malignancy, either glandular or squamous (P < 0.0001). Twenty-two of 33 malignant cases showed P-cadherin membrane staining. None of the 30 benign cases tested showed membrane staining, but three of them displayed an aberrant nuclear P-cadherin expression. Conclusions: We concluded that P-cadherin can be used to discriminate between malignant and benign cervical cytological specimens, but not to discriminate glandular from squamous lesions.