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Characterization of monocarboxylate transporters (MCTs) expression in soft tiss...
Pinheiro, Céline; Penna, Valter; Santos, Filipa Morais; Abrahão-Machado, Lucas F.; Ribeiro, Guilherme; Curcelli, Emílio C.; Olivieri, Marcus V.Background: Soft tissue sarcomas (STSs) are a group of neoplasms, which, despite current therapeutic advances, still confer a poor outcome to half of the patients. As other solid tumors, STSs exhibit high glucose consumption rates, associated with worse prognosis and therapeutic response. As highly glycolytic tumors, we hypothesized that sarcomas should present an increased expression of lactate transporters (M...
CD147 immunohistochemistry discriminates between reactive mesothelial cells and...
Pinheiro, Céline; Longatto Filho, Adhemar; Ramos, Tony R.; Pereira, Helena; Bedrossian, Carlos; Michael, Claire; Schmitt, Fernando C.; Baltazar, FátimaMalignant mesothelioma (MM) is a rare form of cancer. Its histopathological diagnosis is very difficult, as it exhibits a number of different appearances that can be misinterpreted as metastatic invasion or atypical hyperplasia. Thus, there is an urgent need to identify adequate markers to distinguish between benign and malignantcells, allowing the implementation of appropriate therapies and, possibly, specifi...
Characterization of PAR1 and FGFR1 expression in invasive breast carcinomas : p...
Tiburcio, Marta; Costa, Sandra Maria Araújo da; Duarte, Maria de Fátima Pereira; Schmitt, Fernando C.; Filho, A. L.Breast cancer is the most common cause of cancer mortality among women worldwide. Among the several factors associated with breast cancer development, angiogenesis plays an essential role and has currently emerged as a potential diag¬nostic, prognostic and therapeutic target. Protease-activated receptor 1 (PAR1) and fibroblast growth factor receptor 1 (FGFR1) have important activities in tumor angiogenesis and ...
Lactate-induced il-8 pathway in endothelial cells-letter
Pinheiro, Céline; Longatto Filho, Adhemar; Nogueira, Rosete; Schmitt, Fernando C.; Baltazar, FátimaVegran and colleagues proposed a model in which the lactate released from tumor cells through MCT4 would be taken up by endothelial cells via the MCT1 transporter and stimulate angiogenesis, using human umbilical vein endothelial cells (HUVECs) as model of tumor endothelial cells. By analyzing a total of 505 cases of human tumor samples immunostained for MCT1, we do not confirm plasma membrane expression of MCT...
Role of monocarboxylate transporters in human cancers : state of the art
Pinheiro, Céline; Longatto Filho, Adhemar; Azevedo, João Silva; Casal, Margarida; Schmitt, Fernando C.; Baltazar, FátimaMonocarboxylate transporters (MCTs) belong to the SLC16 gene family, presently composed by 14 members. MCT1-MCT4 are proton symporters, which mediate the transmembrane transport of pyruvate, lactate and ketone bodies. The role of MCTs in cell homeostasis has been characterized in detail in normal tissues, however, their role in cancer is still far from understood. Most solid tumors are known to rely on glycolys...
GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prog...
Pinheiro, Céline; Sousa, Bárbara; Albergaria, André; Paredes, Joana; Dufloth, Rozany; Vieira, Daniella; Schmitt, Fernando C.; Baltazar, FátimaWe thank Dr. Vitor Carneiro (pathologist from the Hospital do Divino Espírito Santo, Ponta Delgada, São Miguel, Azores), for his help in retrieving the breast cancer samples for this study. ; The goal of the present work was to evaluate the correlation of glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CAIX) with the monocarboxylate transporters 1 (MCT1) and 4 (MCT4) and their chaperone, CD147, in bre...
Wound healing activity of the human antimicrobial peptide LL37
Ramos, Reinaldo Rodrigues; Silva, João P.; Rodrigues, A. C.; Costa, Raquel; Schmitt, Fernando C.; Soares, Raquel; Guardão, Luísa; Vilanova, ManuelAntimicrobial peptides (AMPs) are part of the innate immune system and are generally defined as cationic, amphipathic peptides, with less than 50 amino acids, including multiple arginine and lysine residues. The human cathelicidin antimicrobial peptide LL37 can be found at different concentrations in many different cells, tissues and body fluids and has a broad spectrum of antimicrobial and immunomodulatory act...
Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and the...
Pinheiro, C??line; Reis, R. M.; Ricardo, Sara; Longatto Filho, Adhemar; Schmitt, Fernando C.; Baltazar, F??timaExpression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. ; Monocarboxylate transporters (MCTs) are important cellular pH regulators in cancer cells; however, the value of MCT expression in cancer is still poorly understood. In the present study, we analysed MCT1, MCT2, and MCT4 protein expression in breast, colon, lung, and ovary neoplasms, as well as C...
Lactoferrin and cancer disease prevention
Rodrigues, L. R.; Teixeira, J. A.; Schmitt, Fernando C.; Paulsson, Marie; Lindmark-Mässon, HelenaLactoferrin (LF) is an iron-binding glycoprotein that is composed of the transferrin family and is predominantly found in the products of the exocrine glands located in the gateways of the digestive, respiratory, and reproductive systems, suggesting a role in the non-specific defence against invading pathogens. Additionally, several physiological roles have been attributed to LF, namely regulation of iron homeo...
A comparative study of recombinant and native frutalin binding to human prostat...
Oliveira, Carla Cristina Marques de; Teixeira, J. A.; Schmitt, Fernando C.; Domingues, LucíliaBackground Numerous studies indicate that cancer cells present an aberrant glycosylation pattern that can be detected by lectin histochemistry. Lectins have shown the ability to recognise these modifications in several carcinomas, namely in the prostate carcinoma, one of the most lethal diseases in man. Thus, the aim of this work was to investigate if the α-D-galactose-binding plant lectin frutalin is able to d...
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