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Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas an...
Moniz, Sónia; Martinho, Olga; Pinto, Filipe; Sousa, Bárbara; Loureiro, Claúdia; Oliveira, Maria José; Moita, Luis Ferreira; Honavar, MrinaliniThe gene encoding protein kinase WNK2 was recently identified to be silenced by promoter hypermethylation in gliomas and meningiomas, suggesting a tumour-suppressor role in these brain tumours. Following experimental depletion in cell lines, WNK2 was further found to control GTP-loading of Rac1, a signalling guanosine triphosphatase involved in cell migration and motility. Here we show that WNK2 promoter methyl...
Área funerária romana em Évora: dos restos ósseos aos rituais funerários
Fernandes, Teresa Matos; Paredes, Joana; Rebocho, Lurdes; Lopes, Maria Helena; Janeirinho, VâniaApós intervenção parcial numa área funerária romana (datada entre os sécs. I e II d.C.), identificada em Évora, foi analisado em laboratório o conteúdo osteológico e odontológico de 11 estruturas funerárias de cremação e uma de inumação. Cruzando os resultados da análise antropológica com o espólio arqueológico associado foram obtidas informações em torno dos rituais funerários, nomeadamente os associados à cre...
GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prog...
Pinheiro, Céline; Sousa, Bárbara; Albergaria, André; Paredes, Joana; Dufloth, Rozany; Vieira, Daniella; Schmitt, Fernando C.; Baltazar, FátimaWe thank Dr. Vitor Carneiro (pathologist from the Hospital do Divino Espírito Santo, Ponta Delgada, São Miguel, Azores), for his help in retrieving the breast cancer samples for this study. ; The goal of the present work was to evaluate the correlation of glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CAIX) with the monocarboxylate transporters 1 (MCT1) and 4 (MCT4) and their chaperone, CD147, in bre...
Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointest...
Velho, Sérgia; Oliveira, Carla; Paredes, Joana; Sousa, Sónia; Leite, Marina; Matos, Paulo; Milanezi, Fernanda; Ribeiro, Ana Sofia; Mendes, NunoMixed lineage kinase 3 (MLK3) is a serine/threonine kinase, regulating MAPkinase signalling, in which cancer-associated mutations have never been reported. In this study, 174 primary gastrointestinal cancers (48 hereditary and 126 sporadic forms) and 7 colorectal cancer cell lines were screened for MLK3 mutations. MLK3 mutations were significantly associated with MSI phenotype in primary tumours (P = 0.0005), o...
P-cadherin overexpression Is an indicator of clinical outcome in invasive breas...
Paredes, Joana; Albergaria, André; Oliveira, João T.; Jerónimo, Carmen; Milanezi, Fernanda; Schmitt, Fernando C.Purpose: P-cadherin overexpressionhas been reported in breast carcinomas,where itwas associated with proliferative high-grade histological tumors. This study aimed to analyze P-cadherin expression in invasive breast cancer and to correlate it with tumor markers, pathologic features, and patient survival. Another purpose was to evaluate the P-cadherin promoter methylation pattern as the molecularmechanismunderly...
P-cadherin expression in glandular lesions of the uterine cervix detected by li...
Longatto Filho, Adhemar; Albergaria, André; Paredes, Joana; Moreira, M. A. R.; Milanezi, Fernanda; Schmitt, Fernando C.Objective: To study P-cadherin aberrant expression as a possible marker for cervical adenocarcinomas in cytological samples. Methods: We studied P-cadherin immunoexpression in liquid-based cervical cytology samples of biopsy-proven cervical lesions. Results: We found a statistically significant correlation between P-cadherin expression and a cytological diagnosis of malignancy, either glandular or squamous (P <...
Novel and classic myoepithelial/stem cell markers in metaplastic carcinomas of ...
Reis Filho, Jorge S.; Milanezi, Fernanda; Paredes, Joana; Silva, Paula; Pereira, Emílio M.; Maeda, Sueli A.; Carvalho, Leda V. de; Schmitt, Fernando C.Metaplastic carcinomas of the breast (MCBs) are unusual neoplasms characterized by an admixture of glandular epithelial components, which frequently exhibit features of squamous differentiation, and mesenchymal malignant components. Regardless of the presence of myoepithelial features in MCB, no consensus concerning their putative histogenesis has yet been achieved. Recently, novel putative myoepithelial marker...
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