Encontrados 68 documentos, a visualizar página 1 de 7
In vitro degradation and in vivo biocompatibility of chitosan-poly(butylene suc...
Pinto, A. R.; Martins, Ana M.; Carlos, Magda; Correlo, V. M.; Sol, P.; Longatto Filho, Adhemar; Battacharya, Mrinal; Reis, R. L.; Neves, N. M.In tissue engineering, the evaluation of the host response to the biomaterial implantation must be assessed to determine the extent of the inflammatory reaction. We studied the degradation of poly(butylene succinate) and chitosan in vitro using lipase and lysozyme enzymes, respectively. The subcutaneous implantation of the scaffolds was performed to assess tissue response. The type of inflammatory cells present...
Self-collection for high-risk HPV detection in Brazilian women using the care H...
Lorenzi, Adriana Tarlá; Fregnani, José Humberto; Possati-Resende, Júlio César; Neto, Cristovam Scapulatempo; Villa, Luisa Lina; Longatto Filho, AdhemarCervical cancer is the second most common cancer among Brazilian women. High-risk human papillomavirus (hr-HPV) persistence is the primary cause of cervical neoplasia. Early detection of hr-HPV is important for identifying women at risk for developing cervical lesions. Approximately 85% of new cases of cervical cancer worldwide and 50% of the total cervical cancer deaths occurred in developing countries. Here, ...
Iodine increases and predicts incidence of thyroiditis in NOD mice : histopatho...
Vecchiatt, Stella Maria Pedrossian; Guzzo, Maria Luisa; Caldini, Elia Garcia; Bisi, Hélio; Longatto Filho, Adhemar; Lin, Chin JiaProlonged intake of large amounts of iodine has been reported to increase the incidence of hypothyroidism in humans, as well as in animals which are prone to spontaneously developing autoimmune thyroiditis. We sought to investigate the histopathological consequences of large amounts of dietary iodine on the thyroid gland and observe the occurrence of lymphocytic infiltration associated with the time of exposure...
A hospital based cohort study of colorectal cancer cases treated at Braga Hospi...
Martins, Sandra; Reis, R. M.; Baltazar, Fátima; Longatto Filho, AdhemarBackground: Colorectal cancer (CRC) is the third most common cancer and the fourth most frequent cause of cancer death worldwide. Nonetheless, despite being a frequent cancer on which many epidemiological international studies have already been written, Portuguese epidemiological data are scarce and in particular there are very few specific data for Minho Region, which is traditionally recognized as a high inci...
Ki-67 and CD100 immunohistochemical expression is associated with local recurre...
Campos, Marcelo; Campos, Sivana Gisele Pegorin de; Ribeiro, Guilherme Gomes; Eguchi, Flávia Coltri; Silva, Sandra Regina Morini daSoft tissue sarcomas (STSs) are a heterogeneous group of mesenchymal tumors of >50 subtypes. However, STSs represent <1% of types of cancer. Despite this low frequency, the disease is aggressive and treatment, when possible, is based on traditional chemotherapies. A number of cases of resistance to adjuvant therapies have been reported. Metastases are commonly identified in STS patients during diagnosis and the...
RKIP Inhibition in cervical cancer Is associated with higher tumor aggressive b...
Martinho, Olga; Pinto, Filipe; Granja, Sara Costa; Gonçalves, Vera M.; Longatto Filho, Adhemar; Reis, R. M.; Loreto, Celso di; Rosner, Marsha R.Cervical cancer is one of the most common cancers in women worldwide, being high-risk group the HPV infected, the leading etiological factor. The raf kinase inhibitory protein (RKIP) has been associated with tumor progression and metastasis in several human neoplasms, however its role on cervical cancer is unclear. In the present study, 259 uterine cervix tissues, including cervicitis, cervical intraepithelial ...
Clinicopathological correlation and prognostic significance of VEGF-A, VEGF-C, ...
Martins, Sandra; Longatto Filho, AdhemarBACKGROUND: Colorectal cancer (CRC) is the third most common type of cancer and the fourth most frequent cause of cancer death. Literature indicates that vascular endothelial growth factor is a predominant angiogenic factor and that angiogenesis plays an important role in the progression of CRC. PATIENTS AND METHODS: The present series consisted of tissue samples obtained from 672 patients who had undergone lar...
Absence of RKIP expression is an independent prognostic biomarker for gastric c...
Martnho, Olga; Longatto Filho, Adhemar; Reis, R. M.; Simões, Kleber; Jacob, Carlos Eduardo; Zilberstein, Bruno; Bresciani, CláudioGastric cancer is a leading cause of cancer-related mortality, and the presence of lymph node metastasis an important prognostic factor. Downregulation of RKIP has been associated with tumor progression and metastasis in several types of neoplasms, being currently categorized as a metastasis suppressor gene. Our aim was to determine the expression levels of RKIP in gastric tissues and to evaluate its impact in ...
Update on colorectal carcinomatosis - from molecular biology to diagnosis and m...
Martins, Sandra; Longatto Filho, AdhemarAfter liver metastases, Peritoneal Carcinomatosis (PC) is the second most frequent cause of death in patients with Co-lorectal Cancer (CRC), although the precise incidence of Colorectal Cancer Peritoneal Carcinomatosis is not known, as the majority of the diagnostic studies cannot detect the disease in its initial stages, nowadays, the diagnosis of peritoneal carcinomatosis remains a challenge. The molecular bi...
Could alarmingly high rates of negative diagnoses in remote rural areas be mini...
Fregnani, José Humberto; Neto, Cristovam Scapulatempo; Haikel Junior, Raphael L.; Saccheto, T.; Campacci, N.; Mauad, Edmund C.; Longatto Filho, AdhemarObjective: It was the aim of this study to compare diagnostic performances of the BD SurePath (TM) liquid-based Papanicolaou test (LBC) and the conventional Papanicolaou test (CPT) in cervical samples of women from remote rural areas of Brazil. Study Design: Specimens were collected by mobile units provided by Barretos Cancer Hospital. This report evaluates the manual screening arm of the RODEO study. Of 12,048...
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