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GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prog...
Pinheiro, Céline; Sousa, Bárbara; Albergaria, André; Paredes, Joana; Dufloth, Rozany; Vieira, Daniella; Schmitt, Fernando C.; Baltazar, FátimaWe thank Dr. Vitor Carneiro (pathologist from the Hospital do Divino Espírito Santo, Ponta Delgada, São Miguel, Azores), for his help in retrieving the breast cancer samples for this study. ; The goal of the present work was to evaluate the correlation of glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CAIX) with the monocarboxylate transporters 1 (MCT1) and 4 (MCT4) and their chaperone, CD147, in bre...
Transcription factors and epigenetics in breast cancer : new findings in CDH3/P...
Albergaria, AndréTese de doutoramento em Ciências da Saúde – Ciências da Saúde ; Breast cancer is the leading cause of cancer amongst women in the westernized world. It is a heterogeneous disease ranging from premalignant hyperproliferation to invasive and metastatic carcinomas. Disease progression is poorly understood but is likely due to the accumulation of genetic alterations leading to widespread changes in gene expression...
P-cadherin overexpression Is an indicator of clinical outcome in invasive breas...
Paredes, Joana; Albergaria, André; Oliveira, João T.; Jerónimo, Carmen; Milanezi, Fernanda; Schmitt, Fernando C.Purpose: P-cadherin overexpressionhas been reported in breast carcinomas,where itwas associated with proliferative high-grade histological tumors. This study aimed to analyze P-cadherin expression in invasive breast cancer and to correlate it with tumor markers, pathologic features, and patient survival. Another purpose was to evaluate the P-cadherin promoter methylation pattern as the molecularmechanismunderly...
P-cadherin expression in glandular lesions of the uterine cervix detected by li...
Longatto Filho, Adhemar; Albergaria, André; Paredes, Joana; Moreira, M. A. R.; Milanezi, Fernanda; Schmitt, Fernando C.Objective: To study P-cadherin aberrant expression as a possible marker for cervical adenocarcinomas in cytological samples. Methods: We studied P-cadherin immunoexpression in liquid-based cervical cytology samples of biopsy-proven cervical lesions. Results: We found a statistically significant correlation between P-cadherin expression and a cytological diagnosis of malignancy, either glandular or squamous (P <...
Distribution of p63, a novel myoepithelial marker, in fine-needle aspiration bi...
Reis Filho, Jorge S.; Milanezi, Fernanda; Amendoeira, Isabel; Albergaria, André; Schmitt, Fernando C.BACKGROUND. The presence of myoepithelial cells (MECs) in fine-needle aspiration biopsies (FNAB) of the breast constitute an important criterion used to diagnose benign breast lesions. However, MECs sometimes have a distorted cytomorphology, and most of the previously evaluated myoepithelial markers do not have satisfactory sensitivity and specificity. p63, a recently characterized p53 homolog, is a nuclear tra...
Naked nuclei revisited : p63 immunoexpression
Reis Filho, Jorge S.; Albergaria, André; Milanezi, Fernanda; Amendoeira, Isabel; Schmitt, Fernando C.The presence of naked nuclei (NN) in cytological preparations of fibroadenomas is a well-known finding. Regardless of their importance on the differential diagnosis of fibroadenoma and other benign lesions of the breast, the origin of NN remains elusive. Despite previous efforts to characterize them, the lack of a reliable nuclear marker for myoepithelial cells impaired definitive conclusions. We performed a sy...
p63 expression in normal skin and usual cutaneous carcinomas
Reis Filho, Jorge S.; Torlo, Beatriz; Albergaria, André; Schmitt, Fernando C.Background: p63 is a p53 homologue that is mapped to chromosome 3q27. This gene encodes six different isoforms, which have either transactivating or dominant negative effects on p53-reporter genes. It has been described that in contrast to p53, p63 seems not to be associated with tumor predisposition, as neither p63 knockout mouse models nor germline p63 mutations are related to an increased risk of tumorigenes...
The shallow-water Polyplacophora of the Azores and some comments on the biogeog...
Ávila, Sérgio P.; Albergaria, AndréThe Mollusc's reference collection of the Department of Biology of the University of the Azores (DBUA) was checked for Polyplacophora. A taxonomic list is given and new data is provided regarding the geographic distribution and bactymetric range of the Azorean Polyphacophora. Some comments are made about the biogeographical relationships of Gastropoda, Bivalvia, Cephalopoda and Polyplacophora of the Azores.
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