In vitro and computational studies of transdermal perfusion of nanoformulations...

• Autor(es): Martins, M. ; Azoia, Nuno G. ; Ribeiro, Artur J. ; Shimanovich, Ulyana ; Silva, Carla ; Paulo, Artur Cavaco
• Data: 2013
• Identificador Persistente: http://hdl.handle.net/1822/24342
• Origem: RepositóriUM - Universidade do Minho
• Assunto(s): Protein; Surfactant; Nanodispersion; Transdermal perfusion; Hydrophilic macromolecules
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

Transdermal perfusion of a large protein is reported for the first time, using a nanoemulsion of bovine serum albumin (66 kDa) of 160 nm prepared by a solid-in-oil (S/O) process. Molecular dynamics simulations confirmed skin permeation by these formulations, with integration of the protein into the lipid bilayers. These results demonstrate the real possibility of delivering large proteins transdermally for a range of medical and cosmetic applications.