Casbane diterpene as a promising natural antimicrobial agent against biofilm-as...

• Author(s): Carneiro, Victor Alves ; Santos, Hélcio Silva dos ; Arruda, Francisco Vassiliepe Sousa ; Bandeira, Paulo Nogueira ; Albuquerque, Maria Rose Jane Ribeiro ; Pereira, M. O. ; Henriques, Mariana ; Cavada, Benildo Sousa ; Teixeira, Edson Holanda
• Date: 2011
• Persistent ID: http://hdl.handle.net/1822/16646
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Casbane diterpene; Biofilm-associated infections control; Natural antimicrobials; Bacteria and yeast
• Document Type: Article
• Language: English

Description

Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened, with minimal active concentrations ranging between 125 and 500 µg/mL. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms