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Cyclodextrins as encapsulation agents for plant bioactive compounds
Pinho, Eva; Grootveld, Martin; Soares, Graça M. B.; Henriques, MarianaAbstract Plants possess a wide range of molecules capable of improve healing: fibre, vitamins, phytosterols, and further sulphur-containing compounds, carotenoids, organic acid anions and polyphenolics. However, they require an adequate level of protection from the environmental conditions to prevent losing their structural integrity and bioactivity. Cyclodextrins are cyclic oligosaccharides arising from the de...
Antifungal activity of phenolic compounds identified in flowers from the North ...
Alves, Carlos Tiago; Ferreira, Isabel C.F.R.; Barros, Lillian; Silva, Sónia; Azeredo, Joana; Oliveira, Rosário; Henriques, MarianaTo evaluate the antifungal effect of gallic acid, catechin, luteolin and quercetin, phenolic compounds identified from flowers of North Eastern Portugal, against Candida planktonic and biofilm cells. Materials & methods: The MICs were determined in Candida planktonic cells and the effect of phenolic compounds on Candida biofilms was assessed through quantification of CFUs. Results: MIC values demonstrated that ...
Decoction, infusion and hydroalcoholic extract of Origanum vulgare L.: differen...
Martins, Natália; Barros, Lillian; Santos-Buelga, Celestino; Henriques, Mariana; Ferreira, Isabel C.F.R.Bioactivity of oregano methanolic extracts and essential oils is well known. Nonetheless, reports using aqueous extracts are scarce, mainly decoction or infusion preparations used for therapeutic applications. Herein, the antioxidant and antibacterial activities, and phenolic compounds of the infusion, decoction and hydroalcoholic extract of oregano were evaluated and compared. The antioxidant activity is relat...
Antibacterial potential of Northeastern Portugal wild plant extracts and respec...
Pinho, Eva; Ferreira, Isabel C.F.R.; Barros, Lillian; Carvalho, Ana Maria; Soares, Graça; Henriques, MarianaThe present work aims to assess the antibacterial potential of phenolic extracts, recovered from plants obtained on the North East of Portugal, and of their phenolic compounds (ellagic, caffeic, and gallic acids, quercetin, kaempferol, and rutin), against bacteria commonly found on skin infections. The disk diffusion and the susceptibility assays were used to identify the most active extracts and phenolic compo...
Candidiasis: predisposing factors, prevention, diagnosis and alternative treatment
Martins, Natália; Ferreira, Isabel C.F.R.; Barros, Lillian; Silva, Sónia; Henriques, MarianaCandidiasis is the most common opportunistic yeast infection. Candida species and other microorganisms are involved in this complicated fungal infection, but Candida albicans continues to be the most prevalent. In the past two decades, it has been observed an abnormal overgrowth in the gastrointestinal, urinary and respiratory tracts, not only in immunocompromised patients, but also related to nosocomial infect...
The impact of microcarrier culture optimization on the glycosylation profile of...
Costa, A. R.; Withers, Joanne; Rodrigues, E.; McLoughlin, Niaobh; Henriques, Mariana; Oliveira, Rosário; Rudd, Pauline M.; Azeredo, JoanaMicrocarriers are widely used for the large-scale culture of attachment-dependent cells with increased cell densities and, ultimately, higher product yield. In these processes, the specific culture conditions can affect the quality of the product, which is closely related to its glycosylation pattern. Furthermore, the lack of studies in the area reinforces the need to better understand the effects of microcarri...
Antifungal activity and detailed chemical characterization of Cistus ladanifer ...
Barros, Lillian; Alves, Carlos; Duenas, M.; Silva, Sónia Carina; Carvalho, Ana Maria; Henriques, Mariana; Santos-Buelga, CelestinoThe life-threatening mycoses caused by opportunistic fungal pathogens (mainly species from the genus Candida) associated with nosocomial infections, are one of the major health problems in our days. Therefore, it is crucial to identify new compounds, especially natural ones, that are active against the most broaden spectrum of Candida species. Herein, a screening of the antifungal potential of a phenolicextract...
Silver colloidal nanoparticles : effect on matrix composition and structure of ...
Monteiro, D. R.; Silva, Sónia Carina; Negri, M.; Gorup, L. F.; Camargo, E. R.; Oliveira, Rosário; Barbosa, D. B.; Henriques, MarianaAim : The aim of this study was to assess the effect of different silver nanoparticles (SN) concentrations on the matrix composition and structure of Candida albicans and Candida glabrata biofilms. Methods and Results : Candida biofilms were developed in 6-well microtiter plates during 48 h. After, these biofilms were exposed to 13·5 or 54 μg SN ml−1 for 24 h. Then, extracellular matrices were extracted from bi...
Corrosion behaviour of titanium in the presence of Streptococcus mutans
Souza, J. C. M.; Ponthiaux, Pierre; Henriques, Mariana; Oliveira, Rosário; Teughels, W.; Celis, J. P.; Rocha, L. A.Objective The main aim of this in vitro study was to evaluate the influence of Streptococcus mutans on the corrosion of titanium. Methods S. mutans biofilms were formed on commercially pure titanium (CP-Ti) square samples (10 mm × 10 mm × 1 mm) using a culture medium enriched with sucrose. Open circuit potential (OCP) and electrochemical impedance spectroscopy (EIS) measurements were used to evaluate the cor...
Characterization of phenolic compounds in wild medicinal flowers from Portugal ...
Barros, Lillian; Alves, Carlos; Dueñas, M.; Silva, Sónia Carina; Oliveira, Rosário; Carvalho, Ana Maria; Henriques, Mariana; Santos-Buelga, CelestinoIn the present work, the phenolic compounds of Castanea sativa, Filipendula ulmaria and Rosa micrantha flowers from Northeastern Portugal were characterized by HPLC–DAD–ESI/MS. Furthermore, it was performed a screening of their antifungal potential against Candida species (Candida albicans, Candida glabrata, Candida parapsilosis and Candida tropicalis). C. sativa sample gave the highest amount of phenolic comp...
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