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Prophylactic outcomes of casbane diterpene in Candida albicans and Candida glab...

Biofilms are surface associated communities of microorganisms embedded within a self-produced extracellular matrix and adhered on inert and biotic surfaces. These biological consortia are considered the most prevalent growth form of microorganisms. Biofilm formation is a potent virulence factor for a number of Candida species, as it confers significant tolerance to antimicrobial therapy, primarily by limiting t...

Casbane diterpene activity on mixed biofilms of P. aeruginosa and Candida species

Casbane diterpene as a promising natural antimicrobial agent against biofilm-as...

Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit mi...