Novel 1-hydroxy-1,1-bisphosphonates derived from indazole: synthesis and charac...

• Author(s): Teixeira, Fátima C. ; Antunes, Inês F. ; Curto, Maria João Marcelo ; Neves, M. ; Teixeira, António P. S.
• Date: 2009
• Persistent ID: http://hdl.handle.net/10400.9/703
• Origin: Repositório do LNEG
• Subject(s): Bisphosphonates; Indazole; N-1 and N-2 isomers; Spectroscopic characterization
• Document Type: Article
• Language: English

Description

Bisphosphonates (BPs) are an important class of drugs used in the treatment of abnormal calcium metabolism diseases. The first syntheses of bisphosphonates derived from indazole, substituted at the N-1, N-2 and C-3 positions are reported. The 1-hydroxy-1,1-bisphosphonates were synthesized from the corresponding carboxylic acid or acyl chloride compounds, by two different methods. These BPs have a side chain with different lengths ((CH2)n, n = 0-5) between the indazole ring and the bisphosphonate group.