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Profile of antimicrobial potential of fifteen Hypericum species from Portugal 

The aim of the present study was the search for the industrial exploitation potential of 15 Hypericum species crops from Portugal. Although Hypericum perforatum is well known worldwide, scarce studies have been published of Hypericum spp. identified in Portugal. Extracts from 15 Hypericum species were screened for its antimicrobial activities against 2 Gram- and 2 Gram+ bacteria, 4 non-tuberculous Mycobacterium...

New 1-Hydroxy-1,1-bisphosphonates derived from 1H-Pyrazolo[3,4-b]pyridine: Synt...

A number of 1H-pyrazolo[3,4-b]pyridine derivatives, starting from 2-chloro-3-formyl pyridine, was synthesized to obtain new 1-hydroxybisphosphonates, a class of compounds with potential biological interest. Spectroscopic data were used to characterize all compounds and to identify N-1 and N-2 regioisomers, and mono- and bisphosphonates derivatives. X-ray diffractometry studies of compound 7a confirmed the propo...

Impacto na saúde e medidas relacionadas com armas químicas e outros agentes quí...

Neste trabalho é abordado o impacto da utilização de produtos químicos perigosos em acções de terrorismo e são propostas medidas de intervenção que devem ter em conta os cenários previsíveis. Considerando-se primordial a protecção da saúde de grupos alvo, pretende-se sensibilizar as entidades responsáveis para medidas específicas a serem adoptadas por médicos, laboratórios, enfermeiros e brigadas de intervenção...

New substituted indazole and condensed pyrazole bisphosphonetes

Novel 1-hydroxy-1,1-bisphosphonates derived from indazole: synthesis and charac...

Bisphosphonates (BPs) are an important class of drugs used in the treatment of abnormal calcium metabolism diseases. The first syntheses of bisphosphonates derived from indazole, substituted at the N-1, N-2 and C-3 positions are reported. The 1-hydroxy-1,1-bisphosphonates were synthesized from the corresponding carboxylic acid or acyl chloride compounds, by two different methods. These BPs have a side chain wit...

New indazole and condensed pyrazole bisphosphonates

Synthesis and characterization of novel hydroxy- and aminobisphosphonates

Bisphosphonates (BPs) are a family of drugs that are successfully used in the treatment of various calcium-related disorders such as Pagetμs disease, osteoporosis and bone metastases. In addition, functional BPs have been also used in the treatment of metal intoxication and as novel ligands for well-defined radioactive metal complexes that can be used in imagiology, scintigraphy and radiotherapy applications [1...