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Síntese de ácidos e ésteres mono- e bisfosfónicos derivados do indazole

Os bisfosfonatos (BPs) constituem um grupo de compostos derivados do ácido bisfosfónico e dos seus sais, onde o grupo P-O-P foi substituído por um bioisoster, resultando na estrutura P-C-P, que lhe confere maior estabilidade química e metabólica. Os bisfosfonatos (BPs) constituem uma classe importante de fármacos, com aplicações terapêuticas no tratamento de doenças do metabolismo mineral do osso, como a osteop...

New Phosphonic Acids and Esters Derived from Indazole: Synthesis and Biological...

Bisphosphonates (BPs) are a group of compounds derived from bisphosphonic acid and their salts, with a P-C-P structure which confers higher metabolic and chemical stability. They are an important class of drugs with therapeutic applications in the treatment of diseases of bone mineral metabolism such as osteoporosis and Paget's disease. These compounds have also shown activity in other areas, such as antitumor ...

Synthesis and characterization of new benzimidazole phosphonates for hybrid mat...

Fuel cells are electrochemical devices that convert the chemical energy stored in a fuel, directly and efficiently into electrical energy and are a promising and clean alternative to traditional energy fuels [1]. The roton-exchange membrane fuel cells (PEMFCs) are considered a promising type of electrochemical device for power generation. The proton exchange membrane (PEM) is a key part for the operation of PEM...

Síntese de ácidos e ésteres mono- e bisfosfónicos derivados do indazole

Os bisfosfonatos (BPs) constituem um grupo de compostos derivados do ácido bisfosfónico e dos seus sais, onde o grupo P-O-P foi substituído por um bioisoster, resultando na estrutura P-C-P, que lhe confere maior estabilidade química e metabólica. Os bisfosfonatos (BPs) constituem uma classe importante de fármacos, com aplicações terapêuticas no tratamento de doenças do metabolismo mineral do osso, como a osteop...

New azaheterocyclic aromatic diphosphonates for hybrid materials for fuel cell ...

New azaheterocyclic aromatic diphosphonate derivatives of benzimidazole and benzotriazole were synthesized by nickel-catalyzed Arbuzov reaction of 4,7-dibromo-2,1,3-benzothiadiazole with triethyl phosphite, followed by reductive sulfur extrusion reaction and cyclization. This new strategy allowed us to obtain these compounds with high efficiency, with the generation of these azaheterocyclic aromatic diphosphona...

New 1-Hydroxy-1,1-bisphosphonates derived from 1H-Pyrazolo[3,4-b]pyridine: Synt...

A number of 1H-pyrazolo[3,4-b]pyridine derivatives, starting from 2-chloro-3-formyl pyridine, was synthesized to obtain new 1-hydroxybisphosphonates, a class of compounds with potential biological interest. Spectroscopic data were used to characterize all compounds and to identify N-1 and N-2 regioisomers, and mono- and bisphosphonates derivatives. X-ray diffractometry studies of compound 7a confirmed the propo...

New phosphonic acids and esters derived from Indazole: synthesis and biological...

Bisphosphonates (BPs) are a group of compounds derived from bisphosphonic acid and their salts, with a P-C-P structure which confers higher metabolic and chemical stability. They are an important class of drugs with therapeutic applications in the treatment of diseases of bone mineral metabolism such as osteoporosis and Paget's disease. These compounds have also shown activity in other areas, such as antitumor ...

Molecular modeling of the interaction of novel hydroxy- and aminobisphosphonate...

Bisphosphonates (BPs) are a class of drugs widely used in the treatment of several metabolic bone disorders associated with increased bone resorption. Although BPs can directly inhibit the cellular activity of osteoclasts, their ability to adsorb on bone mineral is also an important factor in determining their potency and duration of action. In this study, we performed a molecular mechanics analysis of the mole...

Molecular modeling of the interaction of novel hydroxy-and aminobisphosphonates...

Bisphosphonates (BPs) are a class of drugs widely used in the treatment of several metabolic bone disorders associated with increased bone resorption. Although BPs can directly inhibit the cellular activity of osteoclasts, their ability to adsorb on bone mineral is also an important factor in determining their potency and duration of action. In this study, we performed a molecular mechanics analysis of the mole...

Bisfosfonatos derivados do indazole: síntese e avaliação da actividade biológica