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Síntese de ácidos e ésteres mono- e bisfosfónicos derivados do indazole
Teixeira, António P. S.; Afonso, Silvânia S.; Martins, M. Rosário; Teixeira, Fátima C.Os bisfosfonatos (BPs) constituem um grupo de compostos derivados do ácido bisfosfónico e dos seus sais, onde o grupo P-O-P foi substituído por um bioisoster, resultando na estrutura P-C-P, que lhe confere maior estabilidade química e metabólica. Os bisfosfonatos (BPs) constituem uma classe importante de fármacos, com aplicações terapêuticas no tratamento de doenças do metabolismo mineral do osso, como a osteop...
New Phosphonic Acids and Esters Derived from Indazole: Synthesis and Biological...
Teixeira, António P. S.; Afonso, Silvânia S.; Martins, M. Rosário; Teixeira, Fátima C.Bisphosphonates (BPs) are a group of compounds derived from bisphosphonic acid and their salts, with a P-C-P structure which confers higher metabolic and chemical stability. They are an important class of drugs with therapeutic applications in the treatment of diseases of bone mineral metabolism such as osteoporosis and Paget's disease. These compounds have also shown activity in other areas, such as antitumor ...
Novel 1-hydroxy-1,1-bisphosphonates derived from indazole: synthesis and charac...
Teixeira, Fátima C.; Antunes, Inês F.; Curto, M. João M.; Neves, M.; Teixeira, António P. S.Bisphosphonates (BPs) are an important class of drugs used in the treatment of abnormal calcium metabolism diseases. The first syntheses of bisphosphonates derived from indazole, substituted at the N-1, N-2 and C-3 positions are reported. The 1-hydroxy-1,1-bisphosphonates were synthesized from the corresponding carboxylic acid or acyl chloride compounds, by two different methods. These BPs have a side chain wit...
Novel 1-hydroxy-1,1-bisphosphonates derived from indazole: synthesis and charac...
Teixeira, Fátima C.; Antunes, Inês F.; Curto, Maria João Marcelo; Neves, M.; Teixeira, António P. S.Bisphosphonates (BPs) are an important class of drugs used in the treatment of abnormal calcium metabolism diseases. The first syntheses of bisphosphonates derived from indazole, substituted at the N-1, N-2 and C-3 positions are reported. The 1-hydroxy-1,1-bisphosphonates were synthesized from the corresponding carboxylic acid or acyl chloride compounds, by two different methods. These BPs have a side chain wit...
A supramolecular zigzag chain of organometallic dipoles mediated by PF6 2- anions
Duarte, M. Teresa; Piedade, M. Fátima M.; Robalo, M. Paula; Teixeira, António P. S.; Garcia, M. HelenaComplex Fe( 5-cyclopentadienyl)(PMe3)[P(OPh)3](4–NCC6H4NO2) [PF6] has been characterized by spectroscopic and X-ray diffraction in order to evaluate the tuning of the electron density at the metal center and the extension ofthe delocalization on the molecule due to the presence of phosphite and phosphine co-ligands. The compound crystallizes in the centrosymmetric space group P21/c which destroys the possibil...
Synthesis of new donor/acceptor 5-cyclopentadienyl and 5-indenyliron(II) comp...
Garcia, M. Helena; Robalo, M. Paula; Teixeira, António P. S.; Dias, A. R.; Piedade, M. Fátima M.; Duarte, M. TeresaNew complexes of the type [Fe( 5-Cp or Ind)(L)(L )(p-NCR)][BF4] (L, L =CO, P(OC6H5)3, P(C6H5)3; R=C6H4N(CH3)2, C6H4NO2, (E)-C(H) C(H)C6H4NO2, (E)-C(H) C(H)C6H4N(CH3)2) have been synthesised and characterised. Spectroscopic data were analysed in order to evaluate the tuning of the electronic density at the metal centre and the extension of the -delocalisation on the molecule, due to the presence of coligands w...
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