Author(s):
Gomes, André R. 
; Correia, Susana S. ; Carvalho, Ana Luísa ; Duarte, Carlos B.
Date: 2003
Persistent ID: http://hdl.handle.net/10316/7904
Origin: Estudo Geral - Universidade de Coimbra
Document details
Regulation of AMPA Receptor Activity, Synaptic Targeting and Recycling: Role in...
Description
The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors for the neurotransmitter glutamate are oligomeric structures responsible for most fast excitatory responses in the central nervous system. The activity of AMPA receptors can be directly regulated by protein phosphorylation, which may also affect the interaction with intracellular proteins and, consequently, their recycling and localization to defined postsynaptic sites. This review focuses on recent advances in understanding the dynamic regulation of AMPA receptors, on a short- and long-term basis, and its implications in synaptic plasticity. http://dx.doi.org/10.1023/A:1025610122776
The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors for the neurotransmitter glutamate are oligomeric structures responsible for most fast excitatory responses in the central nervous system. The activity of AMPA receptors can be directly regulated by protein phosphorylation, which may also affect the interaction with intracellular proteins and, consequently, their recycling and localization to defined postsynaptic sites. This review focuses on recent advances in understanding the dynamic regulation of AMPA receptors, on a short- and long-term basis, and its implications in synaptic plasticity. http://dx.doi.org/10.1023/A:1025610122776
Document Type
Article
Language English
Language English
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