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Proposta de método para a avaliação da sustentabilidade em obra

Tese de mestrado integrado. Engenharia Civil (Área de Especialização de Construções Civis). Faculdade de Engenharia. Universidade do Porto. 2012

Revegetation of abandoned copper mines: The role of seed banks and soil amendments

Terras contaminadas, quer com poluentes orgânicos ou inorgânicos, são um problema muito comum. As áreas mineiras são uma das principais causas de entrada de metais pesados no ambiente, além de terem um forte impacto visual. A revegetação é o método mais eficaz para prevenir a erosão e a consequente disseminação de contaminantes para áreas circundantes. No entanto, o crescimento das plantas é condicionado por fa...

Estudo dos casos de ameloblastomas diagnosticados no Laboratório de Patologia B...

Implementação de um sistema de dosímetria “in-vivo” em Radioterapia Externa : a...

Dissertação de mestrado em Física dos Materiais Avançados ; Um dos grandes objectivos da dosimetria em Radioterapia é assegurar que a dose prescrita pelo radioterapeuta é realmente a depositada no paciente. Para isso, é necessário o uso de pequenos detectores que permitam a avaliação dos parâmetros dos feixes. Tradicionalmente, a dosimetria “in vivo” tem sido feita com dosímetros TLD ou díodos que possuem algu...

Characterization of alternatively spliced isoforms of AMPA receptor subunits en...

Glutamate receptors of the [alpha]-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type play an important role in synaptic plasticity and contribute to cell death under excitotoxic conditions. AMPA receptors form heterotetramers of four homologous subunits (GluR1-4), which exist in two functionally different isoforms, flip and flop, generated by alternative splicing. We identified transcripts for alte...

Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

Machado-Joseph disease (MJD) is a fatal, dominant neurodegenerative disorder. MJD results from polyglutamine repeat expansion in the MJD-1 gene, conferring a toxic gain of function to the ataxin-3 protein. In this study, we aimed at overexpressing ataxin-3 in the rat brain using lentiviral vectors (LV), to generate an in vivo MJD genetic model and, to study the disorder in defined brain regions: substantia nigr...

NEDD8: A new ataxin-3 interactor

Machado-Joseph disease (MJD/SCA3) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG tract in the coding portion of the ATXN3 gene. The presence of ubiquitin-positive aggregates of the defective protein in affected neurons is characteristic of this and most of the polyglutamine disorders. Recently, the accumulation of the neural precursor cell expressed developmentally downregul...

BDNF regulates the expression and traffic of NMDA receptors in cultured hippoca...

The neurotrophin BDNF regulates the activity-dependent modifications of synaptic strength in the CNS. Physiological and biochemical evidences implicate the NMDA glutamate receptor as one of the targets for BDNF modulation. In the present study, we investigated the effect of BDNF on the expression and plasma membrane abundance of NMDA receptor subunits in cultured hippocampal neurons. Acute stimulation of hippoc...

NPY in rat retina is present in neurons, in endothelial cells and also in micro...

NPY is present in the retina of different species but its role is not elucidated yet. In this work, using different rat retina in vitro models (whole retina, retinal cells in culture, microglial cell cultures, rat Müller cell line and retina endothelial cell line), we demonstrated that NPY staining is present in the retina in different cell types: neurons, macroglial, microglial and endothelial cells. Retinal c...

PKC Anchoring to GluR4 AMPA Receptor Subunit Modulates PKC-Driven Receptor Phos...

Changes in the synaptic content of 03B1-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)2013type glutamate receptors lead to synaptic efficacy modifications, involved in synaptic plasticity mechanisms believed to underlie learning and memory formation. Early in development, GluR4 is highly expressed in the hippocampus, and GluR4-containing AMPA receptors are inserted into synapses. During synapse maturatio...