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PKC Anchoring to GluR4 AMPA Receptor Subunit Modulates PKC-Driven Receptor Phos...
Gomes, André R.; Correia, Susana S.; Esteban, José A.; Duarte, Carlos B.; Carvalho, Ana LuísaChanges in the synaptic content of 03B1-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)2013type glutamate receptors lead to synaptic efficacy modifications, involved in synaptic plasticity mechanisms believed to underlie learning and memory formation. Early in development, GluR4 is highly expressed in the hippocampus, and GluR4-containing AMPA receptors are inserted into synapses. During synapse maturatio...
Brain-derived neurotrophic factor regulates the expression and synaptic deliver...
Caldeira, Margarida V.; Melo, Carlos V.; Pereira, Daniela B.; Carvalho, Ricardo; Correia, Susana S.; Backos, Donald S.; Carvalho, Ana LuísaBrain-derived neurotrophic factor (BDNF) plays an important role in synaptic plasticity in the hippocampus, but the mechanisms involved are not fully understood. The neurotrophin couples synaptic activation to changes in gene expression underlying long term potentiation and short term plasticity. Here we show that BDNF acutely up-regulates GluR1, GluR2, and GluR3 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propi...
Regulation of AMPA Receptor Activity, Synaptic Targeting and Recycling: Role in...
Gomes, André R.; Correia, Susana S.; Carvalho, Ana Luísa; Duarte, Carlos B.The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors for the neurotransmitter glutamate are oligomeric structures responsible for most fast excitatory responses in the central nervous system. The activity of AMPA receptors can be directly regulated by protein phosphorylation, which may also affect the interaction with intracellular proteins and, consequently, their recycling and localiz...
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