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Characterization of alternatively spliced isoforms of AMPA receptor subunits en...
Gomes, André R.; Ferreira, Joana S.; Paternain, Ana V.; Lerma, Juan; Duarte, Carlos B.; Carvalho, Ana LuísaGlutamate receptors of the [alpha]-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type play an important role in synaptic plasticity and contribute to cell death under excitotoxic conditions. AMPA receptors form heterotetramers of four homologous subunits (GluR1-4), which exist in two functionally different isoforms, flip and flop, generated by alternative splicing. We identified transcripts for alte...
PKC Anchoring to GluR4 AMPA Receptor Subunit Modulates PKC-Driven Receptor Phos...
Gomes, André R.; Correia, Susana S.; Esteban, José A.; Duarte, Carlos B.; Carvalho, Ana LuísaChanges in the synaptic content of 03B1-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)2013type glutamate receptors lead to synaptic efficacy modifications, involved in synaptic plasticity mechanisms believed to underlie learning and memory formation. Early in development, GluR4 is highly expressed in the hippocampus, and GluR4-containing AMPA receptors are inserted into synapses. During synapse maturatio...
Metabotropic glutamate and dopamine receptors co-regulate AMPA receptor activit...
Gomes, André R.; Cunha, Paulo; Nuriya, Mutsuo; Faro, Carlos J.; Huganir, Richard L.; Pires, Euclides V.; Carvalho, Ana Luísa; Duarte, Carlos B.Glutamate receptor phosphorylation has been implicated in several forms of modulation of synaptic transmission. It has been reported that protein kinase A (PKA) can phosphorylate the 03B1-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR4 on Ser842, both in vitro and in vivo. Here, we studied the regulation of GluR4 phosphorylation and intracellular trafficking by PKA and by metabotrop...
Regulation of AMPA Receptor Activity, Synaptic Targeting and Recycling: Role in...
Gomes, André R.; Correia, Susana S.; Carvalho, Ana Luísa; Duarte, Carlos B.The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors for the neurotransmitter glutamate are oligomeric structures responsible for most fast excitatory responses in the central nervous system. The activity of AMPA receptors can be directly regulated by protein phosphorylation, which may also affect the interaction with intracellular proteins and, consequently, their recycling and localiz...
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