Detalhes do Documento

Blood flow in microchannels manufactured by a low cost technique: xurography

Autor(es): Pinto, Elmano cv logo 1 ; Taboada, B. cv logo 2 ; Faustino, V. cv logo 3 ; Cidre, Diana cv logo 4 ; Rodrigues, Raquel Oliveira cv logo 5 ; Miranda, João Mário cv logo 6 ; Garcia, Valdemar cv logo 7 ; Dias, Ricardo P. cv logo 8 ; Lima, R. cv logo 9

Data: 2013

Identificador Persistente: http://hdl.handle.net/10198/8738

Origem: Biblioteca Digital do IPB

Assunto(s): Blood flow; Xurograpgy; Cell free layer; Bifurcations


Descrição
The xurography is a technique that has been used to make molds to produce microchannels. In contrast to soft lithography [1, 2], xurography uses equipments and materials commonly used in the printing industry, such as cutting plotters, vinyl and other materials. The main advantage of this technique is to fabricate microchannels at a reduced cost [3, 4]. The Fahraeus-Lindqvist effect is a well know phenomenon that happens in microcirculation, where red blood cells (RBCs) have tendency to migrate toward the centre of the microtube resulting in a marginal cell-free layer (CFL) at regions adjacent to the wall [5]. Recently several studies showed strong evidence that the formation of the CFL is affected by the geometry of the microchannel [1, 6, 7] and the physiological conditions of the working fluid, such as the hematocrit (Hct) [2, 8]. The main objective of the present work is to fabricate polydimethysiloxane (PDMS) microchannels by using a soft xurography technique in order perform blood flow studies. Additionally, a high-speed video microscopy system is used to measure the CFL thickness in two different geometries, i. e., bifurcations and confluences.
Tipo de Documento Parte ou capítulo de livro
Idioma Inglês
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