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Measurement of red blood cells deformation index in a hyperbolic microchannel
Faustino, V.; Pinho, Diana; Yaginuma, Tomoko; Calhelha, Ricardo C.; Man-Kim, Gyeong; Arana, Sergio; Lima, R.; Ferreira, Isabel C.F.R.; Oliveira, M.S.N.A hyperbolic microchannel was used for the purpose of observing the deformation index of the erythrocytes after contact with human tumour cell line (HCT-15 - colon carcinoma). Three cases were compared and the results showed that the deformation index decreases when erythrocytes are in contact with HCT-15.
Blood flow in microchannels manufactured by a low cost technique: xurography
Pinto, Elmano; Taboada, B.; Faustino, V.; Cidre, Diana; Rodrigues, Raquel Oliveira; Miranda, João Mário; Garcia, Valdemar; Dias, Ricardo P.; Lima, R.The xurography is a technique that has been used to make molds to produce microchannels. In contrast to soft lithography [1, 2], xurography uses equipments and materials commonly used in the printing industry, such as cutting plotters, vinyl and other materials. The main advantage of this technique is to fabricate microchannels at a reduced cost [3, 4]. The Fahraeus-Lindqvist effect is a well know phenomenon t...
Flow of red blood cells in microchannel networks : in vitro studies
Cidre, Diana; Rodrigues, Raquel Oliveira; Faustino, V.; Pinto, Elmano; Pinho, Diana; Bento, David; Fernandes, Carla S.; Dias, Ricardo P.; Lima, R.Human blood is a multiphase biofluid primarily composed by the deformable red blood cells (RBCs) suspended in plasma. Because the complex structure of RBCs, blood exhibits unique flow characteristics on micro-scale level, due to their complex biochemical mechanisms and their response to both shear and extensional flow, which influence the rheological properties and flow behaviour of blood [1,2]. In the past yea...
Separation and deformation of red blood cells in PDMS microchannels
Rodrigues, Raquel Oliveira; Faustino, V.; Pinho, Diana; Pinto, Elmano; Cidre, Diana; Yaginuma, Tomoko; Taboada, B.; Bento, David; Lima, R.Over the years, several experimental techniques were performed in in vitro environments, in an attempt to understand the flow behaviour of blood in microcirculation. Several of these studies were performed in glass capillaries, and have produced significant results with respect to rheological properties of blood [1, 2]. Another way to perform in vitro blood studies is to use microchannels fabricated by soft- li...
Técnicas de separação biomimética em microfluídica
Faustino, V.; Pinho, Diana; Rodriques, R.; Garcia, Valdemar; Lima, R.A separação e a identificação de células são essenciais em várias aplicações biomédicas, incluindo a biologia celular e os métodos de diagnóstico e terapêuticos. O sangue é um fluido não-Newtoniano contendo inúmeras informações preciosas sobre o estado fisiológico e patológico do corpo humano. No entanto, devido à sua complexidade, existem actualmente poucos métodos de análise precisos. A maioria das técnicas c...
Comparison of inverse planning systems based on biological or physical factors:...
Coelho, Carina Marques; Faustino, V.; Heliodoro, H.; Monsanto, Fátima; Sá, Ana Cravo; Varandas, C.Radiotherapy (RT) is one of the most important approaches in the treatment of cancer and its performance can be improved in three different ways: through the optimization of the dose distribution, by the use of different irradiation techniques or through the study of radiobiological initiatives. The first is purely physical because is related to the physical dose distributiuon. The others are purely radiobiolog...
Visualization of the cell-free layer (CFL) in a PDMS microchannel with a micro-...
Pinho, Diana; Yaginuma, Tomoko; Faustino, V.; Pinto, Elmano; Rodrigues, Raquel Oliveira; Cidre, Diana; Pereira, Ana I.; Lima, R.Red blood cells (RBCs) have a tendency to undergo axial migration due to the parabolic velocity profile which results in a high shear stress around wall that forces the RBC to move towards the center induced by the tank treading motion of the RBC membrane. As a result there is a formation of cell-free layer (CFL) with extremely low concentration of cells. Based on this phenomenon several works have proposed mic...
The study of cell behaviour using biomedical microdevices
Faustino, V.Advisors: Rui Lima, Co-advisors: Isabel Ferreira ; The cell culture has become over the years an important discipline for the thorough knowledge of cells behaviour and migration, as also cell-cell interaction. A few years ago it was only possible to create culture systems in vitro systems, however, with the advance of new technologies it has become possible to create culture systems in vivo closer to reality. ...
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