Encontrados 26 documentos, a visualizar página 1 de 3
Blood flow in a bifurcation and confluence microchannel : the effectof the cell...
Pinho, Diana; Bento, David; Rodrigues, Raquel; Fernandes, Carla S.; Garcia, Valdemar; Lima, R.A few detailed studies have been performed in complex in vitro microvascular networks composed by bifurcations and confluences. The main purpose of the present work is to numerically simulate the flow of two distinct fluids through bifurcation and confluence geometries, i. e red blood cells (RBCs) suspended in Dextran40 with about 14% of heamatocrit and pure water. The simulations of pure water and RBCs flows w...
Blood flow in a bifurcation and confluence microchannel : effect of the cell-...
Pinho, Diana; Bento, David; Rodrigues, Raquel; Fernandes, Carla S.; Garcia, Valdemar; Lima, R.A few detailed studies have been performed in complex in vitro microvascular networks composed by bifurcations and confluences. The main purpose of the present work is to numerically simulate the flow of two distinct fluids through bifurcation and confluence geometries, i. e red blood cells (RBCs)suspended in Dextran40 with about 14% of heamatocrit and pure water. The simulations of pure water and RBCs flows we...
Visualization and measurement of red blood cells flowing in microfluidic devices
Rodrigues, Raquel; Pinho, Diana; Faustino, Vera; Yaginuma, T.; Bento, David; Fernandes, Carla S.; Garcia, Valdemar; Lima, R.Several experimental techniques were performed in the past years using in vitro environments, in an attempt to not only understand the blood flow behaviour in microcirculation but also develop microfluidic devices as an alternative clinical methodology to detect blood diseases. Hence, the visualization and measurement of red blood cells (RBCs) flowing in a microfluidic device are important to provide not only e...
Cell-free layer (CFL) measurements in complex geometries: contractions and bifu...
Novais, Susana; Pinho, Diana; Bento, David; Pinto, Elmano; Yaginuma, Tomoko; Fernandes, Carla S.; Garcia, Valdemar; Pereira, Ana I.; Lima, JoséIn this chapter we discuss the cell-free layer (CFL) developed adjacent to the wall of microgeometries containing complex features representative of the microcirculation, such as contractions, expansions, bifurcations and confluences. The microchannels with the different geometries were made of polydimethylsiloxane (PDMS) and we use optical techniques to evaluate the cell-free layer for red blood cells (RBC) su...
Fabricação de microcanais utilizando o método de xurografia: visualização da ca...
Pinto, Elmano; Pinho, Diana; Bento, David; Correia, Teresa Montenegro; Garcia, Valdemar; Dias, Ricardo P.; Miranda, João Mário; Lima, R.No presente estudo, pretendeu-se desenvolver/melhorar uma metodologia de microfabricação de baixo custo, conhecida por xurografia e efectuar a visualização e quantificação da camada livre de células (CLC) junto às paredes para diferentes escoamentos sanguíneos em microcanais.
Blood flow in microchannels manufactured by a low cost technique: xurography
Pinto, Elmano; Taboada, B.; Faustino, V.; Cidre, Diana; Rodrigues, Raquel Oliveira; Miranda, João Mário; Garcia, Valdemar; Dias, Ricardo P.; Lima, R.The xurography is a technique that has been used to make molds to produce microchannels. In contrast to soft lithography [1, 2], xurography uses equipments and materials commonly used in the printing industry, such as cutting plotters, vinyl and other materials. The main advantage of this technique is to fabricate microchannels at a reduced cost [3, 4]. The Fahraeus-Lindqvist effect is a well know phenomenon t...
Técnicas de separação biomimética em microfluídica
Faustino, V.; Pinho, Diana; Rodriques, R.; Garcia, Valdemar; Lima, R.A separação e a identificação de células são essenciais em várias aplicações biomédicas, incluindo a biologia celular e os métodos de diagnóstico e terapêuticos. O sangue é um fluido não-Newtoniano contendo inúmeras informações preciosas sobre o estado fisiológico e patológico do corpo humano. No entanto, devido à sua complexidade, existem actualmente poucos métodos de análise precisos. A maioria das técnicas c...
Fabricação de microcanais utilizando o método de xurografia: visualização da ca...
Pinto, Elmano; Pinho, Diana; Bento, David; Correia, Teresa; Dias, Ricardo; Garcia, Valdemar; Miranda, João MárioNo presente estudo, pretendeu-se desenvolver/melhorar uma metodologia de microfabricação de baixo custo, conhecida por xurografia e efectuar a visualização e quantificação da camada livre de células para diferentes escoamentos sanguíneos em microcanais.
Mass transfer models for oxygen-water co-current flow in vertical bubble columns
Garcia, Valdemar; Teixeira, João SobrinhoThe present work reports a theoretical and experimental study of mass transfer for oxygen-water co-current flow in vertical bubble columns. The axial dispersion of liquid phase was also studied. Experiments were carried out in a 32 mm internal diameter and 5.35 and 5.37 m height columns. The superficial liquid velocity ranged from 0.3 to 0.8 m/s and volumetric flow rate ratio of gas to liquid ranged from 0.015 ...
In vitro blood flow behaviour in microchannels with simple and complex geometries
Garcia, Valdemar; Dias, Ricardo P.; Lima, R.Over the years, various experimental methods have been applied in an effort to understand the blood flow behaviour in microcirculation. The development of optical experimental techniques has contributed to obtain possible explanations on the way the blood flows through microvessels. In recent years, due to advances in computers, optics, and digital image processing techniques, it has become possible to combine ...
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