Matrix Gla protein expression: a complex process involving the use of alternati...

• Author(s): Cancela, Leonor ; Laizé, Vincent ; Conceição, N. ; Tiago, Daniel M. ; Maia, A. T. ; Bensimon-Brito, A. ; Gavaia, Paulo J.
• Date: 2012
• Persistent ID: http://hdl.handle.net/10400.1/4469
• Origin: Sapientia - Universidade do Algarve
• Document Type: Conference Object
• Language: English

Description

Matrix Gla protein (MGP) is a secreted vitamin K-dependent protein (VKD) located in the extracellular matrix and capable of binding calcium through its -carboxyglutamate residues. Although identified in 1983, transcriptional and post-transcriptional mechanisms regulating its expression remain unclear.