Detalhes do Documento

The pathways of cell death in cardiomyocytes induced by vanadate

Autor(es): Aureliano, M. cv logo 1 ; Soares, S. S. cv logo 2 ; Henao, Fernando cv logo 3 ; Gutiérrez-Merino, Carlos cv logo 4

Data: 2007

Identificador Persistente: http://hdl.handle.net/10400.1/1309

Origem: Sapientia - Universidade do Algarve

Assunto(s): Cell death; Vanadate


Descrição
After 24 hours, cardiac myocytes exposure to 10 μM (LD50) vanadate (meta or decavanadate) an increased (30%) of caspase 3-activation was observed, although not significant. On contrary, a significant decrease (40%) of ATP content, characteristic of necrotic cell death was detected. Furthermore, vanadate treatment increased intracellular Ca2+ level from 60 nM to 240 nM, whereas it decreases mitochondria superoxide anion generation and induces mitochondria membrane depolarization (IC50=6.5 μM). In conclusion, micromolar vanadate exposure induces large chances in two major bioenergetic markers in cardiac myocytes: intracellular calcium concentration and superoxide anion mitochondrial production, suggesting a necrotic cell death through a mitochondrial toxic pathway.
Tipo de Documento Documento de conferência
Idioma Inglês
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