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Sarcoplasmic reticulum calcium ATPase is inhibited by organic vanadium coordina...
Aureliano, Manuel; Henao, Fernando; Tiago, Teresa; Duarte, Rui O.; Moura, José J. G.; Baruah, Bharat; Crans, Debbie C.Inorg Chem. 2008 Jul 7;47(13):5677-84. doi: 10.1021/ic702405d ; The general affinity of the sarcoplasmic reticulum (SR) Ca (2+)-ATPase was examined for three different classes of vanadium coordination complexes including a vanadium(V) compound, pyridine-2,6-dicarboxylatodioxovanadium(V) (PDC-V(V)), and two vanadium(IV) compounds, bis(maltolato)oxovanadium(IV) (BMOV), and an analogue of amavadine, bis( N-hydrox...
Vanadate induces necrotic cell death in neonatal rat cardiomyocytes through mit...
Soares, S. S.; Henao, Fernando; Aureliano, M.; Gutiérrez-Merino, CarlosBesides the well-known inotropic effects of vanadium in cardiac muscle, previous studies have shown that vanadate can stimulate cell growth or induce cell death. In this work, we studied the toxicity to neonatal rat ventricular myocytes (cardiomyocytes) of two vanadate solutions containing different oligovanadates distribution, decavanadate (containing decameric vanadate, V10) and metavanadate (containing monom...
The pathways of cell death in cardiomyocytes induced by vanadate
Aureliano, M.; Soares, S. S.; Henao, Fernando; Gutiérrez-Merino, CarlosAfter 24 hours, cardiac myocytes exposure to 10 μM (LD50) vanadate (meta or decavanadate) an increased (30%) of caspase 3-activation was observed, although not significant. On contrary, a significant decrease (40%) of ATP content, characteristic of necrotic cell death was detected. Furthermore, vanadate treatment increased intracellular Ca2+ level from 60 nM to 240 nM, whereas it decreases mitochondria superoxi...
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