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Metais na bioquÃmica e na medicina
Aureliano, M.A BioquÃmica ou QuÃmica da Vida representa uma ciência interdisciplinar que utiliza estratégias e métodos de todas as Ciências Exactas e Naturais. Nos últimos 10 anos, catorze prémios Nobel da QuÃmica, Fisiologia e Medicina foram atribuÃdos na área da BioquÃmica o que reflecte a importância desta área de conhecimento nas Sociedades contemporâneas. A BioquÃmica não se reduz apenas ao estudo dos ...
A quÃmica da vida
Aureliano, M.A BioquÃmica ou QuÃmica da Vida é uma ciência interdisciplinar que utiliza estratégias e métodos de todas as Ciências Exactas e Naturais. Nos últimos 10 anos, foram catorze os prémios Nobel da QuÃmica, Fisiologia e Medicina que foram atribuÃdos na área da BioquÃmica o que reflecte a importância desta área de conhecimento nas Sociedades contemporâneas. A QuÃmica da Vida não se reduz apenas ao e...
A bioquímica na sociedade
Aureliano, M.A Química Biológica, também conhecida por Bioquímica, é uma área do conhecimento que é cada vez mais importante nas sociedades contemporâneas. A Bioquímica, é uma ciência interdisciplinar que utiliza estratégias e métodos de muitas outras, desde a Física à Farmacologia.
Ion pumps as biological targets for decavanadate
Aureliano, M.The putative applications of poly-, oligo- and mono-oxometalates in biochemistry, biology, pharmacology and medicine are rapidly attracting interest. In particular, these compounds may act as potent ion pump inhibitors and have the potential to play a role in the treatment of e.g. ulcers, cancer and ischemic heart disease. However, the mechanism of action is not completely understood in most cases, and even rem...
Recent advances into vanadyl, vanadate and decavanadate interactions with actin
Ramos, S.; Moura, José J. G.; Aureliano, M.Metallomics. 2012 Jan 3;4(1):16-22
Decavanadate, decaniobate, tungstate and molybdate interactions with sarcoplasm...
Fraqueza, Gil; Carvalho, Luís A. E. Batista de; Marques, M. Paula M.; Maia, Luisa; Ohlin, C. André; Casey, William H.; Aureliano, M.Recently we demonstrated that the decavanadate (V10) ion is a stronger Ca2+-ATPase inhibitor than other oxometalates, such as the isoelectronic and isostructural decaniobate ion, and the tungstate and molybdate monomer ions, and that it binds to this protein with a 1 : 1 stoichiometry. The V10 interaction is not affected by any of the protein conformations that occur during the process of calcium translocation ...
Recent advances into vanadyl, vanadate and decavanadate interactions with actin
Ramos, Susana; Moura, José J. G.; Aureliano, M.Although the number of papers about ‘‘vanadium’’ has doubled in the last decade, the studies about ‘‘vanadium and actin’’ are scarce. In the present review, the effects of vanadyl, vanadate and decavanadate on actin structure and function are compared. Decavanadate 51V NMR signals, at 516 ppm, broadened and decreased in intensity upon actin titration, whereas no effects were observed for vanadate monomers, at ...
Os semimetais na origem e evolução da vida
Aureliano, M.; Nolasco, Pedro A.; Silva, João J. R. Fraústo da; Silva, José Armando L.Metalloids in origin and evolution of life. Metalloids have characteristics between metals and non-metals which give them, in some cases, specific properties. At least two of this chemical elements, boron and silicon, are essential to a significant number of living organisms and since some years ago it has been observed that the same metalloids may be involved in the synthesis and stabilization of some molecule...
A comparison between Vanadyl, Vanadate, and decavanadate effects in actin struc...
Aureliano, M.The studies about the interaction of actin with vanadium are seldom. In the present paper the effects of vanadyl, vanadate, and decavanadate in the actin structure and function were compared. Decavanadate clearly interacts with actin, as shown by 51V-NMR spectroscopy. Decavanadate interaction with actin induces protein cysteine oxidation and vanadyl formation, being both prevented by the natural ligand of the p...
Actin cytoskeleton disruption is an early event upon exposure of cerebellar gra...
Tiago, Teresa; Silva, D.; Samhan-Arias, A. K.; Aureliano, M.; Gutiérrez-Merino, CarlosIn this work we have studied the alterations of the actin cytoskeleton in cultured cerebellar granule neurons during exposure to the peroxynitritereleasing agent SIN-1 for less than 2 hours. Actin polymerization state was assessed by fluorescence microscopy ratio images using double labelling for actin filaments (phallacidin) and monomers (DNase-I). In addition, agonists and antagonists of L-type Ca2+ channels ...
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