Autor(es):
Sampaio, Adriana 
; Sousa, Nuno ; Férnandez, Montse ; Vasconcelos, Cristiana ; Shenton, Martha E. ; Gonçalves, Óscar F.
Data: 2008
Identificador Persistente: http://hdl.handle.net/1822/7917
Origem: RepositóriUM - Universidade do Minho
Assunto(s): Williams syndrome; STG; Language; Neurodevelopment
Descrição
Prova tipográfica (In Press) Objective: To evaluate volumes and asymmetry of superior temporal gyrus (STG) and correlate these measures with a
neurocognitive evaluation of verbal performance in Williams syndrome (WS) and in a typically developing age-matched and
sex-matched group.
Background: Despite initial claims of language strength in WS, recent studies suggest delayed language milestones. The STG is
implicated in linguistic processing and is a highly lateralized brain region.
Method: Here, we examined STG volumes and asymmetry of STG in WS patients and in age-matched controls. We also correlated volume of STG with a subset of verbal measures.
Magnetic resonance imaging scans were obtained on a GE 1.5-T magnet with 1.5-mm contiguous slices, and were used to
measure whole gray matter, white matter, and cerebrospinal fluid volumes, and also STG volume.
Results: Results revealed significantly reduced intracranial volume in WS patients, compared with controls. Right and left
STG were also significantly smaller in WS patients. In addition, compared with normal controls, a lack of normal left >right STG asymmetry was evident in WS. Also of note was the finding that, in contrast to controls, WS patients did not reveal a positive correlation between verbal intelligence quotient and left STG volume, which further suggests a disruption in this region of the brain.
Conclusions: In conclusion, atypical patterns of asymmetry and reduced STG volume in WS were observed, which may, in part,
contribute to some of the linguistic impairments found in this cohort of WS patients.
