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Posterior cortical atrophy and Alzheimer’s disease : a meta-analytic review of ...
Alves, Jorge; Soares, José Miguel; Sampaio, Adriana; Gonçalves, Óscar F.This paper presents the first systematic review and meta-analysis of neuropsychological and brain morphometry studies comparing posterior cortical atrophy (PCA) to typical Alzheimer's disease (tAD). Literature searches were conducted for brain morphometry and neuropsychological studies including a PCA and a tAD group. Compared to healthy controls (HC), PCA patients exhibited significant decreases in temporal, o...
Psycholinguistic abilities of children with Williams syndrome
Rossi, Natalia F.; Heinze, Elena Garayzábal; Giacheti, Célia M.; Gonçalves, Óscar F.; Sampaio, AdrianaThe objective of this study was to investigate the psycholinguistic abilities of children with Williams syndrome (WS) and typically developing children using the Illinois Test of Psycholinguistic Abilities (ITPA). Performance on the ITPA was analysed in a group with WS (N = 20, mean age = 8.5 years, SD = 1.62) and two typically developing groups, matched in mental (MA, N = 20, mean age = 4.92 years, SD = 1.14) ...
Uncommon genetic syndromes and narrative production - Case Studies with William...
Garayzábal Heinze, Elena; Capo, Magdalena; Moruno Lopéz, Esther; Gonçalves, Óscar F.; Férnandez, Montserrat; Lens, María; Sampaio, AdrianaThis study compares narrative production among three syndromes with genetic microdeletions: Williams syndrome (WS), Smith-Magenis syndrome (SMS), and Prader-Willi syndrome (PWS), characterized by intellectual disabilities and relatively spared language abilities. Our objective is to study the quality of narrative production in the context of a common intellectual disability. To elicit a narrative production, th...
From semantics to feelings : how do individuals with schizophrenia rate the emo...
Pinheiro, Ana; McCarley, Robert W.; Thompson, Elizabeth; Gonçalves, Óscar F.; Niznikiewicz, MargaretSchizophrenia is characterized by both emotional and language abnormalities. However, in spite of reports of preserved evaluation of valence of affective stimuli, such as pictures, it is less clear how individuals with schizophrenia assess verbal material with emotional valence, for example, the overall unpleasantness/displeasure relative to pleasantness/attraction of a word. This study aimed to investigate how...
Domain-specific and generalization effects of cognitive intervention in diffuse...
Alves, Jorge; Magalhães, Rosana; Castiajo, Paula; Sampaio, Adriana; Gonçalves, Óscar F.; Arantes, MavildeThe neurobehavioral sequelae of traumatic brain injury significantly contribute to the longterm disability associated with this pathology.1 Thus far, there is insufficient evidence for either domainspecific or generalization effects resulting from cognitive intervention in memory, executive functioning, or speed-of-processing domains. Here, we report on the case of an adolescent patient who reduced the aforemen...
How executive functions are related to intelligence in Williams syndrome
Osório, Ana Alexandra Caldas; Cruz, Raquel; Sampaio, Adriana; Garayzábal Heinze, Elena; Martínez-Regueiro, Rocío; Gonçalves, Óscar F.; Carracedo, ÁngelWilliams syndrome is characterized by impairments in executive functions (EFs). However, it remains unknown how distinct types of EFs relate to intelligence in this syndrome. The present study analyzed performance on working memory, inhibiting and shifting, and its links to IQ in a sample of 17 individuals with WS, and compared them with a group of 17 typically developing individuals matched on chronological ag...
Affective picture modulation : Valence, arousal, attention allocation and motiv...
Leite, Jorge; Carvalho, Sandra; Galdo-Álvarez, Santiago; Alves, Jorge; Sampaio, Adriana; Gonçalves, Óscar F.The present study analyses the modulatory effects of affective pictures in the early posterior negativity (EPN), the late positive potential (LPP) and the human startle response on both the peripheral (eye blink EMG) and central neurophysiological levels (Probe P3), during passive affective pictures viewing. The affective pictures categories were balanced in terms of valence (pleasant; unpleasant) and arousal (...
The emotional movie database (EMDB) : a self-report and psychophysiological study
Carvalho, Sandra; Leite, Jorge; Galdo-Álvarez, Santiago; Gonçalves, Óscar F.Film clips are an important tool for evoking emotional responses in the laboratory. When compared with other emotionally potent visual stimuli (e.g., pictures), film clips seem to be more effective in eliciting emotions for longer periods of time at both the subjective and physiological levels. The main objective of the present study was to develop a new database of affective film clips without auditory content...
Analysis of speech fluency in Williams syndrome
Rossi, Natalia F.; Sampaio, Adriana; Gonçalves, Óscar F.; Giacheti, Célia MariaWilliams syndrome (WS) is a neurodevelopmental genetic disorder, often referred as being characterized by dissociation between verbal and non-verbal abilities, although the number of studies disputing this proposal is emerging. Indeed, although they have been traditionally reported as displaying increased speech fluency, this topic has not been fully addressed in research. In previous studies carried out with a...
MRI amygdala volume in Williams syndrome
Capitão, Liliana; Sampaio, Adriana; Sampaio, Cassandra; Vasconcelos, Cristiana; Férnandez, Montse; Garayzábal Heinze, Elena; Shenton, Martha E.One of the most intriguing characteristics of Williams Syndrome individuals is their hypersociability. The amygdala has been consistently implicated in the etiology of this social profile, particularly given its role in emotional and social behavior. This study examined amygdala volume and symmetry in WS individuals and in age and sex matched controls. Magnetic resonance imaging scans were obtained on a GE 1.5-...
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