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MRI amygdala volume in Williams syndrome

Capitão, Liliana; Sampaio, Adriana; Sampaio, Cassandra; Vasconcelos, Cristiana; Férnandez, Montse; Garayzábal Heinze, Elena; Shenton, Martha E.

One of the most intriguing characteristics of Williams Syndrome individuals is their hypersociability. The amygdala has been consistently implicated in the etiology of this social profile, particularly given its role in emotional and social behavior. This study examined amygdala volume and symmetry in WS individuals and in age and sex matched controls. Magnetic resonance imaging scans were obtained on a GE 1.5-...


Autobiographical narratives in Williams Syndrome : structural, process and cont...

Gonçalves, Óscar F.; Pinheiro, Ana P.; Sampaio, Adriana; Férnandez, Montse; Henriques, Margarida Rangel; Sousa, Nuno

Williams syndrome (WS) is a neurodevelopmental disorder, with an intriguing cognitive phenotype. Previous studies found support for an atypical profile of fictional narrative production in WS (Gonçalves et al. The British Journal of Developmental Disabilities, 56(111), 89-109, 2010). This study aimed at testing if the same profile is observed when individuals with WS tell autobiographical narratives. Using a ne...


Williams syndrome hypersociability : a neuropsychological study of the amygdala...

Capitão, Liliana; Sampaio, Adriana; Férnandez, Montse; Sousa, Nuno; Pinheiro, Ana P.; Gonçalves, Óscar F.

Individuals with Williams syndrome display indiscriminate approach towards strangers. Neuroimaging studies conducted so far have linked this social profile to structural and/or functional abnormalities in WS amygdala and prefrontal cortex. In this study, the neuropsychological hypotheses of amygdala and prefrontal cortex involvement in WS hypersociability was explored using three behavioral tasks – facial emoti...


The narrative profile in Williams syndrome: There is more to storytelling than ...

Gonçalves, Óscar F.; Pinheiro, Ana P.; Sampaio, Adriana; Sousa, Nuno; Férnandez, Montse


Cognitive functioning in Williams syndrome : a study in Portuguese and Spanish ...

Sampaio, Adriana; Férnandez, Montse; Henriques, Margarida Rangel; Carracedo, Ángel; Sousa, Nuno; Gonçalves, Óscar F.

Williams Syndrome (WS) is a genetic neurodevelopmental disorder caused by a submicroscopic deletion on chromosome 7 q11.23. This is a systemic disorder in which cardiac problems and mental retardation are the key phenotypic symptoms. Although displaying a general cognitive impairment, they are most often described as exhibiting a peak and valley profile, with relative sparing of language and face processing abi...


Memory abilities in Williams syndrome : dissociation or developmental delay hyp...

Sampaio, Adriana; Sousa, Nuno; Férnandez, Montse; Henriques, Margarida Rangel; Gonçalves, Óscar F.

Williams syndrome (WS) is a neurodevelopmental genetic disorder often described as being characterized by a dissociative cognitive architecture, in which profound impairments of visuo-spatial cognition contrast with relative preservation of linguistic, face recognition and auditory short-memory abilities. This asymmetric and dissociative cognition has been also proposed to characterize WS memory ability, with s...


MRI assessment of superior temporal gyrus in Williams syndrome

Sampaio, Adriana; Sousa, Nuno; Férnandez, Montse; Vasconcelos, Cristiana; Shenton, Martha E.; Gonçalves, Óscar F.

Prova tipográfica (In Press) ; Objective: To evaluate volumes and asymmetry of superior temporal gyrus (STG) and correlate these measures with a neurocognitive evaluation of verbal performance in Williams syndrome (WS) and in a typically developing age-matched and sex-matched group. Background: Despite initial claims of language strength in WS, recent studies suggest delayed language milestones. The STG is imp...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia