Detalhes do Documento

Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147)...

Autor(es): Oliveira, Antônio Talvane Torres cv logo 1 ; Pinheiro, Céline cv logo 2 ; Filho, A. L. cv logo 3 ; Brito, Maria José cv logo 4 ; Martinho, Olga cv logo 5 ; Matos, Delcio cv logo 6 ; Carvalho, André Lopes cv logo 7 ; Vazquez, Vinícius Lima cv logo 8 ; Silva, Thiago Buosi cv logo 9 ; Scapulatempo, Cristovam cv logo 10 ; Saad, Sarhan Sydney cv logo 11 ; Reis, R. M. cv logo 12

Data: 2012

Identificador Persistente: http://hdl.handle.net/1822/24224

Origem: RepositóriUM - Universidade do Minho

Assunto(s): Monocarboxylate transporters; CD147; Cancer metabolism; GISTs


Descrição
Antônio Talvane Torres de Oliveira and Céline Pinheiro contributed equally to the study Prova tipográfica (uncorrected proof) Monocarboxylate transporters (MCTs) have been described to play an important role in cancer, but to date there are no reports on the significance of MCT expression in gastrointestinal stromal tumors (GISTs). The aim of the present work was to assess the value of MCT expression, as well as co-expression with the MCT chaperone CD147 in GISTs and evaluate their clinical-pathological significance. We analyzed the immunohistochemical expression of MCT1, MCT2, MCT4 and CD147 in a series of 64 GISTs molecularly characterized for KIT, PDGFRA and BRAF mutations. MCT1, MCT2 and MCT4 were highly expressed in GISTs. CD147 expression was associated with mutated KIT (p = 0.039), as well as a progressive increase in Fletcher’s Risk of Malignancy (p = 0.020). Importantly, co-expression of MCT1 with CD147 was associated with low patient’s overall survival (p = 0.037). These findings suggest that co-expression of MCT1 with its chaperone CD147 is involved in GISTs aggressiveness, pointing to a contribution of cancer cell metabolic adaptations in GIST development and/or progression.
Tipo de Documento Artigo
Idioma Inglês
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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia