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How to decipher a microbial puzzle on microbial control : hands on
Azevedo, Maria Manuel; Pinheiro, Céline; Miranda, Isabel; Baltazar, FátimaHow to decipher a microbial puzzle on microbial control: hands on ; Antibiotics are among the most commonly prescribed drugs, but they are often misused, contributing to bacterial resistance, being an important public health problem, with clinical/economic impacts. Aiming to contribute to convey information to students on Microbiology/antibiotic use, we developed different teaching activities, with 6th and 9th...
Characterization of monocarboxylate transporters (MCTs) expression in soft tiss...
Pinheiro, Céline; Penna, Valter; Santos, Filipa Morais; Abrahão-Machado, Lucas F.; Ribeiro, Guilherme; Curcelli, Emílio C.; Olivieri, Marcus V.Background: Soft tissue sarcomas (STSs) are a group of neoplasms, which, despite current therapeutic advances, still confer a poor outcome to half of the patients. As other solid tumors, STSs exhibit high glucose consumption rates, associated with worse prognosis and therapeutic response. As highly glycolytic tumors, we hypothesized that sarcomas should present an increased expression of lactate transporters (M...
Monocarboxylate transporters (MCTs) in gliomas : expression and exploitation as...
Gonçalves, Vera M.; Honavar, Mrinalini; Pinheiro, Céline; Martinho, Olga; Pires, Manuel Melo; Pinheiro, Célia; Cordeiro, Michelle; Bebiano, GilBackground. Gliomas exhibit high glycolytic rates, and monocarboxylate transporters (MCTs) play a major role in the maintenance of the glycolytic metabolism through the proton-linked transmembrane transport of lactate. However, their role in gliomas is poorly studied. Thus, we aimed to characterize the expression of MCT1, MCT4, and their chaperone CD147 and to assess the therapeutic impact of MCT inhibition in...
Assessing the impact of a school intervention to promote students' knowledge an...
Pinheiro, Céline; Baltazar, FátimaThe clinical efficacy of antibiotics depends on their correct use. Widespread ignorance and inappropriate attitudes to antibiotic use have been identified among consumers. In order to improve the knowledge of middle-school students on antibiotics and their correct use, 82 ninth-grade students were enrolled in a teaching activity. The teaching activity consisted of a slide show presentation followed by discussio...
CD147 immunohistochemistry discriminates between reactive mesothelial cells and...
Pinheiro, Céline; Longatto Filho, Adhemar; Ramos, Tony R.; Pereira, Helena; Bedrossian, Carlos; Michael, Claire; Schmitt, Fernando C.; Baltazar, FátimaMalignant mesothelioma (MM) is a rare form of cancer. Its histopathological diagnosis is very difficult, as it exhibits a number of different appearances that can be misinterpreted as metastatic invasion or atypical hyperplasia. Thus, there is an urgent need to identify adequate markers to distinguish between benign and malignantcells, allowing the implementation of appropriate therapies and, possibly, specifi...
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147)...
Oliveira, Antônio Talvane Torres; Pinheiro, Céline; Filho, A. L.; Brito, Maria José; Martinho, Olga; Matos, Delcio; Carvalho, André LopesAntônio Talvane Torres de Oliveira and Céline Pinheiro contributed equally to the study ; Prova tipográfica (uncorrected proof) ; Monocarboxylate transporters (MCTs) have been described to play an important role in cancer, but to date there are no reports on the significance of MCT expression in gastrointestinal stromal tumors (GISTs). The aim of the present work was to assess the value of MCT expression, as ...
Lactate-induced il-8 pathway in endothelial cells-letter
Pinheiro, Céline; Longatto Filho, Adhemar; Nogueira, Rosete; Schmitt, Fernando C.; Baltazar, FátimaVegran and colleagues proposed a model in which the lactate released from tumor cells through MCT4 would be taken up by endothelial cells via the MCT1 transporter and stimulate angiogenesis, using human umbilical vein endothelial cells (HUVECs) as model of tumor endothelial cells. By analyzing a total of 505 cases of human tumor samples immunostained for MCT1, we do not confirm plasma membrane expression of MCT...
3-bromopyruvate, butyrate, monocarboxylate transporters, warburg effect
Queirós, Odília; Preto, Ana; Pacheco, António; Pinheiro, Céline; Silva, João Azevedo; Moreira, Roxana; Pedro, Madalena; Ko, Young; Pedersen, PeterThe authors are deeply grateful to Professor André Goffeau (Université Catholique de Louvain-la-Neuve, Belgium) for his contagious vision, valuable discussions at the Conference on 3-BP held in Brussels, 29 October–2 November, 2011 and critical reviewing of the manuscript. The authors also thank Dr. Rita Reis for her technical support in microscopy and image analysis. ; Most malignant tumors exhibit theWarburg...
Role of monocarboxylate transporters in human cancers : state of the art
Pinheiro, Céline; Longatto Filho, Adhemar; Azevedo, João Silva; Casal, Margarida; Schmitt, Fernando C.; Baltazar, FátimaMonocarboxylate transporters (MCTs) belong to the SLC16 gene family, presently composed by 14 members. MCT1-MCT4 are proton symporters, which mediate the transmembrane transport of pyruvate, lactate and ketone bodies. The role of MCTs in cell homeostasis has been characterized in detail in normal tissues, however, their role in cancer is still far from understood. Most solid tumors are known to rely on glycolys...
Impact of EGFR genetic variants on glioma risk and patient outcome
Costa, Bruno Marques; Pereira, Marta Viana; Fernandes, Ricardo; Costa, S.; Linhares, Paulo; Vaz, Rui; Pinheiro, Céline; Lima, Jorge; Soares, PaulaB.M. Costa and M. Viana-Pereira contributed equally to this work; The authors thank the Immunochemotherapy Department of Hospital S. Marcos, and Clinica Laboratorial Dr. Edgar Botelho Moniz, S. Tirso, Portugal, for their helpful assistance in the management of controls ; BACKGROUND: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. ...
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