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Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147)...

Oliveira, Antônio Talvane Torres; Pinheiro, Céline; Filho, A. L.; Brito, Maria José; Martinho, Olga; Matos, Delcio; Carvalho, André Lopes

Antônio Talvane Torres de Oliveira and Céline Pinheiro contributed equally to the study ; Prova tipográfica (uncorrected proof) ; Monocarboxylate transporters (MCTs) have been described to play an important role in cancer, but to date there are no reports on the significance of MCT expression in gastrointestinal stromal tumors (GISTs). The aim of the present work was to assess the value of MCT expression, as ...


Lymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gast...

Oliveira, Antônio Talvane Torres; Reis, R. M.; Afonso, Julieta; Martinho, Olga; Matos, Delcio; Carvalho, André Lopes; Vazquez, Vinícius Lima

This study aimed to assess the distribution of VEGF-C and VEGFR-3 expression in gastrointestinal stromal tumours (GISTs), and to analyse the value of lymphatic vessel density (LVD) in a tumour that is believed to preferentially metastasize through blood vessel conduits. A panel of immunohistochemical antibodies was used to evaluate 51 cases of genetically characterised GISTs: VEGF-C, VEGFR-3, D2-40 (for LVD ass...


Evaluation of the efficacy and reproducibility of cholangiopancreatography by m...

Linhares,Marcelo Moura; Coelho,Rafael Darahen de Souza; Szejnfeld,Jacob; Goldman,Susan Menasce; Gonzalez,Adriano Miziara; Szejnfeld,Denis; Matos,Carla

PURPOSE: To evaluate the accuracy and reproducibility of magnetic resonance cholangiopancreatography (MRCP) in the detection of biliary complications in liver transplanted patients. METHODS: A study was conducted, with blinded review of 28 MRCP exams of 24 patients submitted to liver transplantation. The images were reviewed by two independent observers, at two different moments, regarding the degree of biliary...

Data: 2010   |   Origem: OASIS br

Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colo...

Menezes,Hunaldo Lima de; Jucá,Mário Jorge; Gomes,Edmundo Guilherme de A.; Nunes,Benício L. Bulhões B. P.; Costa,Henrique Oliveira; Matos,Delcio

CONTEXT: Search of tumors markers that allow treatment with higher survival rates, and indicate the response to treatment and recurrence of cancer OBJECTIVE: To analyze the immunoexpression of the proteins p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and correlate them with the clinical-pathological prognostic factors. METHOD: Tissue microarray paraffin blocks were made from colorectal adenocarcinoma tissu...

Data: 2010   |   Origem: OASIS br

Cost-effectiveness analysis on spinal anesthesia versus local anesthesia plus s...

Vaz,Filinto Aníbal Alagia; Abreu,Rone Antônio Alves; Soárez,Patrícia Coelho de; Speranzini,Manlio Basílio; Fernandes,Luís Cesar; Matos,Delcio

CONTEXT: Studies in the area of health economics are still poorly explored and it is known that the cost savings in this area is becoming more necessary, provided that strict criteria. OBJECTIVE: To perform a cost-effectiveness analysis of spinal anesthesia versus local anesthesia plus sedation for loop colostomy closure. METHODS: This was a randomized clinical trial with 50 patients undergoing loop colostomy c...

Data: 2010   |   Origem: OASIS br

Randomized clinical trial comparing spinal anesthesia with local anesthesia wit...

Abreu,Rone Antônio Alves de; Vaz,Filinto Anibal Alagia; Laurino,Ricardo; Speranzini,Manlio Basilio; Fernandes,Luís Cesar; Matos,Delcio

CONTEXT: Recent studies have shown that local anesthesia for loop colostomy closure is as safe as spinal anesthesia for this procedure. OBJECTIVES: Randomized clinical trial to compare the results from these two techniques. METHODS: Fifty patients were randomized for loop colostomy closure using spinal anesthesia (n = 25) and using local anesthesia (n = 25). Preoperatively, the bowel was evaluated by means of c...

Data: 2010   |   Origem: OASIS br

Influência da idade e da doença colorretal na imunocompetência cutânea peri-col...

Salles,Valdemir José Alegre; Saad,Sarhan Sydney; Franco,Marcello Fabiano; Matos,Delcio; Martins,Marcos Roberto

Objetivo: Caracterizar a resposta imunológica presente na camada dérmica da região peri-colostômica. Método: Foram incluídos quarenta e um doentes, portadores de colostomias realizadas há mais de oito semanas. Na determinação imuno-histoquímica foram avaliados os linfócitos Pan T, linfócito T - auxiliar, linfócito T - citotóxico, linfócito B, linfócito T - Natural Killer e os macrófagos. Resultados: Na análise ...

Data: 2009   |   Origem: OASIS br

Correlation between the immunohistochemical expressions of MMP-1, MMP-7 and VEG...

Gomes,Edmundo Guilherme de Almeida; Jucá,Mário Jorge; Menezes,Hunaldo Lima de; Nunes,Benício Luiz Bulhões Barros Paula; Costa,Henrique

PURPOSE: To analyze the expression of metalloproteinase-1, metalloproteinase-7 and vascular endothelial growth factor (VEGF) in colorectal adenocarcinoma, and to correlate these with the clinical-pathological prognostic factors. METHODS: Tumor tissue from 82 patients was fixed in formalin and embedded in paraffin blocks. These samples were analyzed by means of the streptavidin-biotin immunohistochemical method,...

Data: 2009   |   Origem: OASIS br

Relationship between peripheral and mesenteric serum levels of CEA and CA 242 w...

Cardoso,Mauro Lamelas; Fernandes,Luís Cesar; Kim,Su Bong; Matos,Delcio

PURPOSE: To compare histopathological variables and staging in colorectal adenocarcinoma cases with CEA and CA 242 in peripheral and mesenteric blood. METHODS: In 169 individuals underwent surgery for colorectal cancer, CEA and CA 242 were analyzed and compared to mesenteric and peripheral blood and correlated with macroscopic tumor's morphology and size, degree of cell differentiation, venous, neural and lymph...

Data: 2009   |   Origem: OASIS br

Risk factors for indications of intraoperative blood transfusion among patients...

Gonçalves,Iara; Linhares,Marcelo; Bordin,Jose; Matos,Delcio

CONTEXT: Identification of risk factors for requiring transfusions during surgery for colorectal cancer may lead to preventive actions or alternative measures, towards decreasing the use of blood components in these procedures, and also rationalization of resources use in hemotherapy services. This was a retrospective case-control study using data from 383 patients who were treated surgically for colorectal ade...

Data: 2009   |   Origem: OASIS br

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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia