Synthesis and Friedlander reactions of 5-amino-4-cyano-1,3-oxazoles

• Author(s): Carreiras, M. Carmo ; Eleutério, Ana ; Dias, Catarina ; Brito, M. Alexandra ; Brites, Dora ; Marco-Contelles, J. ; Gómez-Sánchez, Elena
• Date: 2007
• Persistent ID: http://hdl.handle.net/10451/3933
• Origin: Repositório da Universidade de Lisboa
• Document Type: Article
• Language: English

Description

The synthesis of 2-substituted 5-amino-4-cyano-1,3-oxazoles (1-4, 6-11) and the Friedländer-type reaction of compounds 1, 3, 4 is described. Compounds 13-17 are tacrine (18) analogues provided by the Friedländer reaction. The anti-cholinesterase activity of compounds 13, 14, 16 and 17 has been investigated.