Encontrados 5 documentos, a visualizar página 1 de 1
Microglia demostrate age-dependent performance and interaction with beta-amyloi...
Lidónio, Gonçalo Manuel da Costa, 1988-; Brites, Dora, 1951-; Dias, Deodália Maria Antunes, 1952-Tese de mestrado. Biologia (Biologia Humana e Ambiente). Universidade de Lisboa, Faculdade de Ciências, 2013 ; Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the elderly and remains without a cure. One of its prominent features is the appearance in the brain of amyloid-beta (Aβ) deposits forming amyloid plaques. Microglia, which are the first line of defense in the brain, are activat...
Identification of a novel deletion in UDP-glucuronosyltransferase gene in a pat...
Costa, Elísio; Santos, Emília Vieira Rosário dos; Lopes, Ana Isabel; Saldanha, Maria Joana; Brites, Dora; Vieira, EmíliaLetter to the Editor
Synthesis and Friedlander reactions of 5-amino-4-cyano-1,3-oxazoles
Carreiras, M. Carmo; Eleutério, Ana; Dias, Catarina; Brito, M. Alexandra; Brites, Dora; Marco-Contelles, J.; Gómez-Sánchez, ElenaThe synthesis of 2-substituted 5-amino-4-cyano-1,3-oxazoles (1-4, 6-11) and the Friedländer-type reaction of compounds 1, 3, 4 is described. Compounds 13-17 are tacrine (18) analogues provided by the Friedländer reaction. The anti-cholinesterase activity of compounds 13, 14, 16 and 17 has been investigated.
Membrane structural changes support the involvement of mitochondria in the bile...
Solá, Susana; Brito, Maria A.; Brites, Dora; Moura, José J. G.; Rodrigues, CecíliaClin Sci (Lond). 2002 Nov;103(5):475-85 ; The accumulation of toxic bile salts within the hepatocyte plays a key role in organ injury during liver disease. Deoxycholate (DC) and glycochenodeoxycholate (GCDC) induce apoptosis in vitro and in vivo, perhaps through direct perturbation of mitochondrial membrane structure and function. In contrast, ursodeoxycholate (UDC) and its taurine-conjugated form (TUDC) appea...
Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order...
Moura, José J. G.; Rodrigues, Cecília M. P.; Solá, Susana; Brito, Maria A.; Brites, DoraBackground/Aims: Unconjugated bilirubin (UCB) impairs crucial aspects of cell function and induces apoptosis in primary cultured neurones. While mechanisms of cytotoxicity begin to unfold, mitochondria appear as potential primary targets. Methods: We used electron paramagnetic resonance spectroscopy analysis of isolated rat mitochondria to test the hypothesis that UCB physically interacts with mitochondria to i...
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