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Electron Ionization Mass Spectrometric Study of Some Substituted 1,3-oxazoles
Salgueiro, Pedro; Dias, Catarina; Carreiras, M. Carmo; Borges, CarlosComunicação oral sob a forma painel ; Heterocyclic compounds are widely used as pharmaceuticals. Tacrine (THA) was the first drug approved for the treatment of Alzheimer’s disease (AD) and a great effort has been made to design and synthesize new THA-analogues in order to evaluate their beneficial effects as therapeutic agents in this disease.1-6 Contrasting with the pharmaceutical interest, mass spectrometric...
Synthesis and Friedlander reactions of 5-amino-4-cyano-1,3-oxazoles
Carreiras, M. Carmo; Eleutério, Ana; Dias, Catarina; Brito, M. Alexandra; Brites, Dora; Marco-Contelles, J.; Gómez-Sánchez, ElenaThe synthesis of 2-substituted 5-amino-4-cyano-1,3-oxazoles (1-4, 6-11) and the Friedländer-type reaction of compounds 1, 3, 4 is described. Compounds 13-17 are tacrine (18) analogues provided by the Friedländer reaction. The anti-cholinesterase activity of compounds 13, 14, 16 and 17 has been investigated.
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