Occupational exposure to formaldehyde: effects of years of exposure in the freq...

• Author(s): Ladeira, Carina ; Viegas, Susana ; Nunes, Carla ; Malta-Vacas, Joana ; Gomes, Mário ; Mendonça, Paula ; Prista, João ; Gomes, Manuel C. ; Brito, Miguel
• Date: 2010
• Persistent ID: http://hdl.handle.net/10400.21/665
• Origin: Repositório Científico do Instituto Politécnico de Lisboa
• Subject(s): Anatomia patológica; Saúde ocupacional; Formaldeído; Factor de risco
• Document Type: Conference Object
• Language: English

Description

Formaldehyde: an important industrial compound used in the manufacture of synthetic resins and chemical compounds such as lubricants and adhesives; also applied as a disinfectant, preservative and in cosmetics productions; relevant workplace exposure to FA also occurs in anatomy, pathology and in mortuaries; classified by IARC as carcinogenic to humans (Group 1), based on sufficient evidence in humans and experimental animals; manifold in vitro studies indicated that FA can induce genotoxic effects in proliferating cultured mammalian cells. Aim of the study: to evaluate if years of exposure induced a genotoxic biomarkers increase, namely MN in lymphocytes and buccal cells, in workers occupationally exposed to FA (factory and pathology anatomy laboratory).