Encontrados 12 documentos, a visualizar página 1 de 2
Exposição profissional a formaldeído em laboratórios de anatomia patológica: qu...
Ladeira, Carina; Viegas, Susana; Carolino, Elisabete; Prista, João; Gomes, Manuel C.; Brito, MiguelO formaldeído é um gás incolor, solúvel na água e que reage rapidamente com o local de contacto. É utilizado nos laboratórios de Anatomia Patológica (AP) como fixador de células e tecidos - importante local de exposição ocupacional ao formaldeído, nomeadamente por médicos patologistas, técnicos de AP e auxiliares de acção médica. Objectivos do estudo: conhecer a exposição a formaldeído nos laboratórios hospital...
Genotoxicity biomarkers in occupational to formaldehyde in pathology anatomy la...
Ladeira, Carina; Gomes, Manuel C.; Brito, MiguelFormaldehyde (FA) the most simple and reactive of all aldehydes, is a colorless, reactive and readily polymerizing gas at normal temperature. It has a pungent, suffocating odour that is recognized by most human subjects at concentrations below 1ppm. According to the Report on Carcinogens, FA ranks 25th in the overall U.S. chemical production with more than 11 billion pounds (5 million tons) produced each year. ...
Lifestyle factors influence in the frequency in buccal micronucleus
Ladeira, Carina; Gomes, Manuel C.; Brito, MiguelGenomic damage is probably the most important fundamental cause of development and degenerative disease. It is also well established that genomic damage is produced by environmental exposure to genotoxins, medical procedures (e.g. radiation and chemicals), micronutrient deficiency (e.g. folate), lifestyle factors (e.g. alcohol, smoking, drugs and stress), and genetic factors such as inherited defects in DNA met...
Effects of age and gender on peripheral lymphocyte micronucleus
Ladeira, Carina; Viegas, Susana; Gomes, Manuel C.; Brito, MiguelAging in humans appears to be associated with genetic instability. The cytokinesis-blocked micronucleus assay (CBMN) is a comprehensive method for measuring chromosome breakage, DNA misrepair, chromosome loss, non-disjunction, necrosis, apoptosis and cytostasis. Age and gender are the most important demographic variables affecting the micronucleus (MN) index and studies report frequencies in females being great...
XRCC3241 Polymorphism influence on genotoxicity biomarkers frequency in workers...
Ladeira, Carina; Gomes, Manuel C.; Brito, MiguelFormaldehyde (FA) is ubiquitous in the environment and is a chemical agent that possesses high reactivity. Occupational exposure to FA has been shown to induce nasopharyngeal cancer and has been classified as carcinogenic to humans (group 1) on the basis of sufficient evidence in humans and sufficient evidence in experimental animals. The exposure to this substance is epidemiologically linked to cancer and nucl...
Effects of exposure to formaldehyde and tobacco smoking on genotoxicity biomarkers
Ladeira, Carina; Gomes, Manuel C.; Brito, MiguelFormaldehyde (FA) is a colour less gas widely used in the industry and hospitals as an aqueous solution, formalin. It is extremely reactive and induces various genotoxic effects in proliferating cultured mammalian cells. Tobacco smoke has been epidemiologically associated to a higher risk of development of cancer, especially in the oral cavity, larynx and lungs, as these are places of direct contact with many c...
Evaluation of the influence of the ADH3 ILE349VAL polymorphism in the frequency...
Ladeira, Carina; Gomes, Manuel C.; Brito, MiguelFormaldehyde (FA) is a colourless gas widely used in the industry and hospitals as an aqueous solution, formalin. It is extremely reactive and induces various genotoxic effects in proliferating cultured mammalian cells. Tobacco smoke has been epidemiologically associated to a higher risk of development of cancer, especially in the oral cavity, larynx and lungs, as these are places of direct contact with many ca...
Formaldehyde's genotoxicity effects in pathology anatomy technologists and medi...
Ladeira, Carina; Viegas, Susana; Prista, J.; Gomes, Manuel C.; Brito, MiguelFormaldehyde (FA) had been considered to be carcinogenic by the International Agency for Research on Cancer (group1), on the basis of sufficient evidence both in humans and in experimental animals, making it a subject of major environmental concern, especially in the occupational context. Manifold in vitro studies clearly indicated that FA is genotoxic, inducing various genotoxic effects in proliferating cultur...
Polimorfismos genéticos no gene XRCC3 e dano no DNA em trabalhadores expostos o...
Ladeira, Carina; Viegas, Susana; Carolino, Elisabete; Gomes, Manuel C.; Brito, MiguelA exposição a formaldeído (FA), classificado como cancerígeno pela International Agency for Cancer Research (IARC), está epidemiologicamente associada a cancro e a alterações nucleares detectáveis pelo ensaio dos micronúcleos por bloqueio da citocinese (CBMN). Este método permite determinar vários marcadores de genotoxicidade, nomeadamente micronúcleos – biomarcadores de quebra ou perda de cromossomas; pontes n...
Occupational exposure to formaldehyde: effects of years of exposure in the freq...
Ladeira, Carina; Viegas, Susana; Nunes, Carla; Malta-Vacas, Joana; Gomes, Mário; Mendonça, Paula; Prista, João; Gomes, Manuel C.; Brito, MiguelFormaldehyde: an important industrial compound used in the manufacture of synthetic resins and chemical compounds such as lubricants and adhesives; also applied as a disinfectant, preservative and in cosmetics productions; relevant workplace exposure to FA also occurs in anatomy, pathology and in mortuaries; classified by IARC as carcinogenic to humans (Group 1), based on sufficient evidence in humans and exper...
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