Development of novel ionic liquids based on ampicillin

• Author(s): Ferraz, Ricardo ; Prudêncio, Cristina ; Branco, Luís ; Marrucho, Isabel ; Araújo, João ; Rebelo, Luís ; Ponte, Manuel Nunes ; Noronha, João Paulo ; Petrovski, Zeljko
• Date: 2012
• Persistent ID: http://hdl.handle.net/10400.22/1704
• Origin: Repositório Científico do Instituto Politécnico do Porto
• Document Type: Article
• Language: English

Description

Novel ionic liquids containing ampicillin as an active pharmaceutical ingredient anion were prepared with good yields by using a new, efficient synthetic procedure based on the neutralization of a moderately basic ammonia solution of ampicillin with different organic cation hydroxides. The relevant physical and thermal properties of these novel ionic liquids based on ampicillin were also evaluated.