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Ammonium ionic liquids as green solvents for drugs
Melo, Catarina I.; Bogel-Lukasik, R.; Ponte, Manuel Nunes; Bogel-Lukasik, EwaA high solubility of antituberculosis antibiotic drugs: isoniazid and pyrazinecarboxamide in ammonium ionic liquids shown in this work, demonstrates the promising perspectives in the drug processing. Solid–liquid equilibrium (SLE) measurements have been made using a dynamic (synthetic) method. Thermophyscial properties such as melting point, enthalpy of fusion, temperatures of phase transitions and correspondi...
Intramolecular C–H insertion catalyzed by dirhodium(II) complexes using CO2 as ...
Zakrzewska, Malgorzata E.; Cal, Pedro M.S.D.; Candeias, Nuno R.; Bogel-Lukasik, R.; Afonso, Carlos A.M.; Ponte, Manuel Nunes; Gois, Pedro M.P.In this work, the intramolecular C–H insertion of diazoacetamides catalyzed by dirhodium(II) complexes and using CO2 as solvent is disclosed. The expected lactams were obtained in yields over 97%. The asymmetric intramolecular C–H insertion was also achieved and the β-lactam 14 was obtained in >97% yield and 65% ee using the chiral dirhodium(II) catalyst Rh2(S-PTTL)4. Finally, the dirhodium(II) complex Rh2(OAc)...
Development of novel ionic liquids based on ampicillin
Ferraz, Ricardo; Prudêncio, Cristina; Branco, Luís; Marrucho, Isabel; Araújo, João; Rebelo, Luís; Ponte, Manuel Nunes; Noronha, João PauloNovel ionic liquids containing ampicillin as an active pharmaceutical ingredient anion were prepared with good yields by using a new, efficient synthetic procedure based on the neutralization of a moderately basic ammonia solution of ampicillin with different organic cation hydroxides. The relevant physical and thermal properties of these novel ionic liquids based on ampicillin were also evaluated.
Synthesis, characterization and antiproliferative activity on cancer cell lines...
Ferraz, Ricardo; Costa-Rodrigues, João; Fernandes, Maria Helena; Branco, Luís; Marrucho, Isabel; Ponte, Manuel Nunes; Prudêncio, CristinaIonic Liquids (ILs) are ionic compounds that possess melting temperature below 100ºC and they have been a topic of great interest since the mid-1990s due to their unique properties. The range of IL uses has been broadened, due to a significant increase in the variety of physical, chemical and biological ILs properties. They are now used as Active Pharmaceutical Ingredients (APIs) and recent interests are focuse...
A novel engineering systems approach for bioengineering education : the MIT-Por...
Tan, Junjay; Newman, Dava J.; Cabral, J. M. S.; Mota, M.; Ponte, Manuel Nunes daThis paper discusses the importance of an engineering systems approach to international bioengineering education and how a new educationalresearch program, the MIT-Portugal Program Bioengineering Systems focus area, aims to develop future global bioengineering leaders. The program, comprising both post-graduate advanced studies and doctoral programs, commences in September 2007. Several other international-coll...
Pressure, Isotope, and Water Co-solvent Effects in Liquid−Liquid Equilibria of ...
Najdanovic-Visak, Vesna; Esperança, José M. S. S.; Rebelo, Luís P. N.; Ponte, Manuel Nunes da; Guedes, Henrique J. R.; Seddon, Kenneth R.Liquid−liquid phase splitting in ternary mixtures that contain a room-temperature ionic liquid and an alcohol aqueous solutionnamely, [bmim][PF6] + ethanol + water and [bmim][NTf2] + 2-methylpropanol + wateris studied. Experimental cloud-point temperatures were obtained up to pressures of 400 bar, using a He−Ne laser light-scattering technique. Although pressurization favors mutual miscibility in the presence o...
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