Encontrados 18 documentos, a visualizar página 1 de 2
Development and biological evaluation of API-ILs based on anti-bacterial and an...
Ferraz, Ricardo; Branco, Luís; Fernandes, Rúben; Prudêncio, Cristina; Noronha, João Paulo; Petrovski, ZeljkoIn recent years Ionic Liquids (ILs) are being applied in life sciences. ILs are being produce with active pharmaceutical drugs (API) as they can reduce polymorphism and drug solubility problems [1] Also ILs are being applied as a drug delivery device in innovative therapies What is appealing in ILs is the ILs building up platform, the counter-ion can be carefully chosen in order to avoid undesirable side effect...
Modulation of osteoclastogenesis by antihypertensive drugs
Oliveira, Teresa; Costa-Rodrigues, João; Ferraz, Ricardo; Prudêncio, Cristina; Fernandes, Maria HelenaDespite its rigid structure, bone is a dynamic tissue that is in constant remodeling. This process requires the action of the bone-resorbing osteoclasts and the bone-synthesing osteoblasts. One of the adverse effects attributed to some antihypertensive agents is the ability to alter normal bone metabolism. However, their effective actions on human bone cells remain to be clarified. In this work, the effects of ...
Negative modulation of human osteoclastogenesis by antiepileptic drugs
Rocha, Sara; Costa-Rodrigues, João; Ferraz, Ricardo; Prudêncio, Cristina; Fernandes, Maria HelenaBone is constantly being molded and shaped by the action of osteoclasts and osteoblasts. A proper equilibrium between both cell types metabolic activities is required to ensure an adequate skeletal tissue structure, and it involves resorption of old bone and formation of new bone tissue. It is reported that treatment with antiepileptic drugs (AEDs) can elicit alterations in skeletal structure, in particular in ...
Development of novel ionic liquids based on ampicillin
Ferraz, Ricardo; Prudêncio, Cristina; Branco, Luís; Marrucho, Isabel; Araújo, João; Rebelo, Luís; Ponte, Manuel Nunes; Noronha, João PauloNovel ionic liquids containing ampicillin as an active pharmaceutical ingredient anion were prepared with good yields by using a new, efficient synthetic procedure based on the neutralization of a moderately basic ammonia solution of ampicillin with different organic cation hydroxides. The relevant physical and thermal properties of these novel ionic liquids based on ampicillin were also evaluated.
Development of novel ionic liquids based on valproate anion
Ferraz, Ricardo; Costa, Alexandra; Marrucho, Isabel; Branco, Luís; Prudêncio, Cristina; Noronha, João Paulo; Petrovski, ZeljkoValproic acid (2-propyl pentanoic acid) is a pharmaceutical drug used for treatment of epileptic seizures absence, tonic-clonic (grand mal), complex partial seizures, and mania in bipolar disorder [1]. Valproic acid is a slightly soluble in water and therefore as active pharmaceutical ingredient it is most commonly applied in form of sodium or magnesium valproate salt [1].However the list of adverse effects of ...
Polimorfismo I/D do gene da enzima conversora da angiotensina
Fernandes, Rúben; Prudêncio, Cristina; Duarte, Fernanda; Silva, Nuno; Silva, Ana LuísaEm Portugal, no ano de 2009, existiam 983 mil indivíduos com Diabetes mellitus (DM), dos quais 90% DM tipo 2 (DM2). Um dos principais factores de risco para o desenvolvimento da DM2 é a obesidade. A DM2 está, desta forma, associada a um estilo de vida sedentário, quer pela diminuição do metabolismo da glicose, quer pela sua associação à obesidade devido ao aumento dos níveis de glicose como consequência da sobr...
Linfangiogénese no tecido adiposo em ratinhos e sua relação com a obesidade: Av...
Fernandes, Rúben; Soares, Raquel; Prudêncio, Cristina; Macedo, Bárbara; Ramalho, Renata; Almeida, JoanaIntrodução: O tecido adiposo é um órgão endócrino dinâmico, secretando factores importantes na regulação do metabolismo lipídico, do fluxo vascular sanguíneo e linfático e função imunológica, entre outros. Em caso de acumulação de tecido adiposo por ingestão de uma dieta gorda, ou por disfunção metabólica, os adipócitos podem desencadear uma reacção inflamatória por falha na drenagem linfática, acumulando-se me...
Synthesis, characterization and antiproliferative activity on cancer cell lines...
Ferraz, Ricardo; Costa-Rodrigues, João; Fernandes, Maria Helena; Branco, Luís; Marrucho, Isabel; Ponte, Manuel Nunes; Prudêncio, CristinaIonic Liquids (ILs) are ionic compounds that possess melting temperature below 100ºC and they have been a topic of great interest since the mid-1990s due to their unique properties. The range of IL uses has been broadened, due to a significant increase in the variety of physical, chemical and biological ILs properties. They are now used as Active Pharmaceutical Ingredients (APIs) and recent interests are focuse...
Ensino e aprendizagem da Bioquímica em Ciências da Saúde: retenção de conhecime...
Prudêncio, Cristina; Fernandes, Rúben; Ferraz, Ricardo; Vieira, Mónica; Fonte, RosáliaNum contexto de reestruturação da formação em Ciências da Saúde baseada em competências, torna-se necessário estudar as diferentes formas de avaliação e o stress que lhe está associado, observando de que forma estas poderão interferir no sucesso académico dos alunos e real aquisição de competências. O objectivo do trabalho foi avaliar estas questões no âmbito da Bioquímica de diferentes cursos de Tecnologias da...
Extended-spectrum β-lactamases from the North of Portugal in the boundaries to ...
Fernandes, Rúben; Ferraz, Ricardo; Vieira, Mónica; Amador, Paula; Brito, Luísa; Coelho, Pedro; Silva, Nuno; Oliveira, C.; Prudêncio, CristinaDuring the past 15 years, emergence and dissemination of third-generation cephalosporins resistance in nosocomial Enterobacteriaceae became a serious problem worldwide, due to the production of extended-spectrum-β-lactamases (ESBLs). The aim of this study was to investigate among the presence of ESBL-producing enterobacteria among Portuguese clinical isolates nearby Spain, to investigate the antimicrobial susce...
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