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Development and biological evaluation of API-ILs based on anti-bacterial and an...
Ferraz, Ricardo; Branco, Luís; Fernandes, Rúben; Prudêncio, Cristina; Noronha, João Paulo; Petrovski, ZeljkoIn recent years Ionic Liquids (ILs) are being applied in life sciences. ILs are being produce with active pharmaceutical drugs (API) as they can reduce polymorphism and drug solubility problems [1] Also ILs are being applied as a drug delivery device in innovative therapies What is appealing in ILs is the ILs building up platform, the counter-ion can be carefully chosen in order to avoid undesirable side effect...
Development of novel ionic liquids based on ampicillin
Ferraz, Ricardo; Prudêncio, Cristina; Branco, Luís; Marrucho, Isabel; Araújo, João; Rebelo, Luís; Ponte, Manuel Nunes; Noronha, João PauloNovel ionic liquids containing ampicillin as an active pharmaceutical ingredient anion were prepared with good yields by using a new, efficient synthetic procedure based on the neutralization of a moderately basic ammonia solution of ampicillin with different organic cation hydroxides. The relevant physical and thermal properties of these novel ionic liquids based on ampicillin were also evaluated.
Development of novel ionic liquids based on valproate anion
Ferraz, Ricardo; Costa, Alexandra; Marrucho, Isabel; Branco, Luís; Prudêncio, Cristina; Noronha, João Paulo; Petrovski, ZeljkoValproic acid (2-propyl pentanoic acid) is a pharmaceutical drug used for treatment of epileptic seizures absence, tonic-clonic (grand mal), complex partial seizures, and mania in bipolar disorder [1]. Valproic acid is a slightly soluble in water and therefore as active pharmaceutical ingredient it is most commonly applied in form of sodium or magnesium valproate salt [1].However the list of adverse effects of ...
Synthesis, characterization and antiproliferative activity on cancer cell lines...
Ferraz, Ricardo; Costa-Rodrigues, João; Fernandes, Maria Helena; Branco, Luís; Marrucho, Isabel; Ponte, Manuel Nunes; Prudêncio, CristinaIonic Liquids (ILs) are ionic compounds that possess melting temperature below 100ºC and they have been a topic of great interest since the mid-1990s due to their unique properties. The range of IL uses has been broadened, due to a significant increase in the variety of physical, chemical and biological ILs properties. They are now used as Active Pharmaceutical Ingredients (APIs) and recent interests are focuse...
New ionic liquids and salts derived from β-Lactam antibiotics
Ferraz, Ricardo; Branco, Luís; Marrucho, Isabel; Fernandes, Rúben; Prudêncio, Cristina; Noronha, João Paulo; Petrovski, ZeljkoIn recent years ionic liquids (ILs) have been increasing the popularity and the number of applications. Ionic liquids were used mainly as solvent in organic synthesis, but in recent years they are also used in analytical chemistry, separation chemistry and material science. Additional to significant developments in their chemical properties and applications, ionic liquids are now bringing unexpected opportunit...
Preparation and characterization of beta-lactam antibiotic as Ionic liquids and...
Ferraz, Ricardo; Fernandes, Rúben; Prudêncio, Cristina; Branco, Luís; Marrucho, Isabel; Noronha, João Paulo; Petrovski, ZeljkoWith the increase of bacterial resistance a large number of therapeutic strategies have been used to fight different kind of infections. In recent years ionic liquids (ILs) have been increasing the popularity and the number of applications. First ionic liquids were used mainly as solvent in organic synthesis, but now they are used in analytical chemistry, separation chemistry and material science among others....
Fungidal and bacterial activity of N,N-dimethyl-4-(2,2,2-trichloro-1-(phenylami...
Ferraz, Ricardo; Petrovski, Zeljko; Fernandes, Rúben; Noronha, João Paulo; Prudêncio, CristinaN,N-dimethyl-4-((phenylamino)methyl)aniline (1) was prepared by condensation of aniline and 4-(dimethylamino)benzaldehyde [1] N,N-dimethyl-4-(2,2,2-trichloro-1-(phenylamino)ethyl)aniline (2) was synthesized by trichloromethylation of the imine (N,N-dimethyl-4-((phenylimino)methyl)aniline (1)) with trichloroacetic anhydride under microwave irradiation [2] (Sheme 1). The present work reports the study of bact...
Antimicrobial activity of pyrazine and quinoxaline N,N’-dioxide heterocyclic c...
Vieira, Mónica; Ferraz, Ricardo; Fernandes, Rúben; Noronha, João Paulo; Silva, M.; Prudêncio, CristinaThe nitrogen heterocyclic organic compounds 1,4 dioxide pyrazine and quinoxaline derivatives have been widely studied due to their potential use as synthetic drugs. The thermochemical study of three N,N´-dioxides: 2,3,5-trimethylpyrazine-1,4-dioxide, tetramethylpyrazine-1,4-dioxide and 6-chloro-2,3-dimethilquinoxaline 1,4-dioxide has been recently developed in order to establish relationships among the energeti...
Metabolitos secundários do fruto de Arbutus unedo L.(Medronho)
Noronha, João Paulo da Costa deDissertação apresentada para obtenção do grau de Doutor em Química, especialidade em Química Orgânica pela Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia
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