Oxidative behaviour of apomorphine and its metabolites

• Author(s): Garrido, J. M. P. J. ; Delerue-Matos, C. ; Borges, M. F. M. ; Macedo, T. R. A. ; Oliveira-Brett, A. M.
• Date: 2002
• Persistent ID: http://hdl.handle.net/10316/4827
• Origin: Estudo Geral - Universidade de Coimbra
• Subject(s): Apomorphine; Oxidative behaviour; Electrochemistry
• Document Type: Article
• Language: English

Description

The metabolism of apomorphine is quite complex due to interactions with proteins and other tissue components that affect its pharmacokinetic profile. The electrochemical oxidation mechanism of apomorphine and of some synthesised apomorphine derivatives was studied. It was found to be related to the reaction of o-diphenol and tertiary amine groups and strongly dependent on pH. http://www.sciencedirect.com/science/article/B6W72-44GDWT0-2/1/3b3b44dfb6b0c11a8d094971768f0a58