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Ochratoxin A contamination of bread – Portugal nationwide survey during winter ...
Duarte, S.; Bento, J.M.V.; Pena, A.; Lino, C.M.; Pereira, J.A.; Delerue-Matos, C.; Oliva-Teles, T.; Morais, S.; Correia, M.; Oliveira, M.B.P.P.Ochratoxin A (OTA) remains one of the most important mycotoxins known, due to its ubiquitous occurrence, wide range of susceptible food commodities and observed toxic effects, in both animals and humans. The reported toxic effects include carcinogenic, nephrotoxic, teratogenic, neurotoxic and immunotoxic.
Ochratoxin A content in urine from Bragança and Alentejo: a compartive analysis...
Duarte, S.; Bento, J.M.V.; Pena, A.; Lino, C.M.; Pereira, J.A.; Delerue-Matos, C.; Oliva-Teles, T.; Morais, S.; Correia, M.; Oliveira, M.B.P.P.Ochratoxin A (OTA) is a mycotoxin which possesses a variety of toxic effects, including enzyme inhibition, immunosuppression, teratogenicity, nephrotoxicity, and carcinogenicity. It is produced by fungi for which foodstuffs such as beans, cereals, fruits, and seeds constitute an ideal growing media. It has proven itself at least partly resistant to food processing methods, meaning it is also present in derived ...
Voltammetric Oxidation of Drugs of Abuse II. Codeine and Metabolites
Garrido, J. M. P. J.; Delerue-Matos, C.; Borges, F.; Macedo, T. R. A.; Oliveira-Brett, A. M.The oxidation of codeine on glassy carbon electrodes has been studied in detail using differential pulse voltammetry. The results obtained using a glassy carbon electrode clearly show a much more complex oxidation mechanism than that previously reported when platinum and gold electrodes were used. To clarify the codeine oxidative profile, several metabolites and analogues of this alkaloid, codeine N-oxide, norc...
Voltammetric Oxidation of Drugs of Abuse I. Morphine and Metabolites
Garrido, J. M. P. J.; Delerue-Matos, C.; Borges, F.; Macedo, T. R. A.; Oliveira-Brett, A. M.A detailed study of the electrochemical oxidative behavior of morphine in aqueous solution is reported. Through the synthesis of several metabolites and derivatives, pseudomorphine, morphine N-oxide, normorphine, dihydromorphine and 2-(N,N-dimethylaminomethyl)morphine, and their voltammetric study it was possible to identify the oxidation peaks for morphine. The anodic waves are related with the oxidation of ph...
Voltammetric Oxidation of Drugs of Abuse III. Heroin and Metabolites
Garrido, J. M. P. J.; Delerue-Matos, C.; Borges, F.; Macedo, T. R. A.; Oliveira-Brett, A. M.The oxidative behavior of heroin in aqueous solution is reported. In order to identify its oxidation peaks, several metabolites, 6-monoacetylmorphine, 3-monoacetylmorphine and norheroin, were synthesized and their electrochemical behavior studied using differential pulse voltammetry. The anodic waves observed for heroin correspond to the oxidation of the tertiary amine group and its follow-up product (secondary...
Electrochemical and Spectroscopic Studies of the Oxidation Mechanism of the Her...
Garrido, E. M.; Lima, J. L. F. C.; Delerue-Matos, C.; Borges, F.; Silva, A. M. S.; Piedade, J. A. P.; Brett, A. M. OliveiraElectrochemical oxidation of propanil in deuterated solutions was studied by cyclic, differential pulse, and square wave voltammetry using a glassy carbon microelectrode. The oxidation of propanil in deuterated acid solutions occurs at the nitrogen atom of the amide at a potential of +1.15 V vs Ag/AgCl. It was also found that, under the experimental conditions used, protonation at the oxygen atom of propanil oc...
Oxidative behaviour of apomorphine and its metabolites
Garrido, J. M. P. J.; Delerue-Matos, C.; Borges, M. F. M.; Macedo, T. R. A.; Oliveira-Brett, A. M.The metabolism of apomorphine is quite complex due to interactions with proteins and other tissue components that affect its pharmacokinetic profile. The electrochemical oxidation mechanism of apomorphine and of some synthesised apomorphine derivatives was studied. It was found to be related to the reaction of o-diphenol and tertiary amine groups and strongly dependent on pH. ; http://www.sciencedirect.com/s...
Electrochemical oxidation of propanil and related N-substituted amides
Garrido, E. M.; Lima, J. L. F. C.; Delerue-Matos, C.; Borges, F.; Silva, A. M. S.; Brett, A. M. OliveiraThe electrochemical behaviour of propanil and related N-substituted amides (acetanilide and N,N-diphenylacetamide) was studied by cyclic and square wave voltammetry using a glassy carbon electrode. Propanil has been found to have chemical stability under the established analytical conditions and showed an oxidation peak at +1.27 V versus Ag/AgCl at pH 7.5. N,N-diphenylacetamide has a higher oxidation potential ...
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