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Pharmacological properties of Tilia europeæ aqueous: screening anxiolytic/sedat...

The extracts or infusions obtained from inflorescences of Tilia europeae have been used in popular medicine as a sedative/anxiolytic drug. The purpose of the present work was to evaluate these possible properties of this extract, by using different behavioural models. The extract, orally administered to mice, prolonged sleeping time, changed the level of anxiety, affected curiosity and locomotor activity and sh...

Monoamine Oxidase Type A and B activities in human uterine arteries: influence ...

Voltammetric Oxidation of Drugs of Abuse II. Codeine and Metabolites

The oxidation of codeine on glassy carbon electrodes has been studied in detail using differential pulse voltammetry. The results obtained using a glassy carbon electrode clearly show a much more complex oxidation mechanism than that previously reported when platinum and gold electrodes were used. To clarify the codeine oxidative profile, several metabolites and analogues of this alkaloid, codeine N-oxide, norc...

Voltammetric Oxidation of Drugs of Abuse I. Morphine and Metabolites

A detailed study of the electrochemical oxidative behavior of morphine in aqueous solution is reported. Through the synthesis of several metabolites and derivatives, pseudomorphine, morphine N-oxide, normorphine, dihydromorphine and 2-(N,N-dimethylaminomethyl)morphine, and their voltammetric study it was possible to identify the oxidation peaks for morphine. The anodic waves are related with the oxidation of ph...

Voltammetric Oxidation of Drugs of Abuse III. Heroin and Metabolites

The oxidative behavior of heroin in aqueous solution is reported. In order to identify its oxidation peaks, several metabolites, 6-monoacetylmorphine, 3-monoacetylmorphine and norheroin, were synthesized and their electrochemical behavior studied using differential pulse voltammetry. The anodic waves observed for heroin correspond to the oxidation of the tertiary amine group and its follow-up product (secondary...

Oxidative behaviour of apomorphine and its metabolites

The metabolism of apomorphine is quite complex due to interactions with proteins and other tissue components that affect its pharmacokinetic profile. The electrochemical oxidation mechanism of apomorphine and of some synthesised apomorphine derivatives was studied. It was found to be related to the reaction of o-diphenol and tertiary amine groups and strongly dependent on pH. ; http://www.sciencedirect.com/s...

Electrochemical oxidation of mitoxantrone at a glassy carbon electrode

Mitoxantrone is an anthracycline used as an antitumour antibiotic for leukaemia and breast cancer treatment, due to its interaction with DNA. However, the molecular mechanism of the antitumour action is not completely understood. Using a glassy carbon electrode the electrochemical oxidation of mitoxantrone was shown to be a complex, pH-dependent, irreversible electrode process involving several metabolites. Com...

Voltammetric behaviour of mitoxantrone at a DNA-biosensor

The surface of an electrochemical glassy carbon electrode was modified with a layer of double-stranded DNA (dsDNA) or with double-stranded DNA conditioned in single-stranded DNA (ssDNA) and was used to investigate mitoxantrone-DNA interactions. Differential pulse and square wave voltammetry were applied to develop an electroanalytical procedure for the determination of mitoxantrone and evaluate its interaction ...