Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenz...

• Author(s): Ferreira, Fernanda M. ; Seiça, Raquel ; Oliveira, Paulo J. ; Coxito, Pedro M. ; Moreno, António J. ; Palmeira, Carlos M. ; Santos, Maria S.
• Date: 2003
• Persistent ID: http://hdl.handle.net/10316/4799
• Origin: Estudo Geral - Universidade de Coimbra
• Subject(s): Diabetes mellitus; Type 1 diabetes; Type 2 diabetes; Goto-Kakizaki (GK) rat; Streptozotocin-induced diabetic (STZ) rat; Mitochondrial permeability transition (MPT)
• Document Type: Article
• Language: English

Description

Several studies have been carried out to evaluate the alterations in mitochondrial functions of diabetic rats. However, results are sometimes controversial, since experimental conditions diverge, including age and strain of used animals. The purpose of this study was to evaluate the metabolic modifications in liver mitochondria, both in the presence of severe (STZ-treated rats) and mild hyperglycaemia [Goto-Kakizaki (GK) rats], when compared with control animals of similar age. Moreover, metabolic alterations were evaluated also at initial and advanced stages of the disease. http://www.sciencedirect.com/science/article/B6T1Y-49FPHJH-1/1/3b97418b61eef86377c47c0fc15ca3d1