Encontrados 26 documentos, a visualizar página 1 de 3
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 su...
Hafner, Angela V.; Dai, Jing; Gomes, Ana P.; Xiao, Chun-Yang; Palmeira, Carlos M.Cardiac failure is a leading cause of age-related death, though its root cause remains unknown. Mounting evidence implicates a decline in mitochondrial function due to increased opening of the mitochondrial permeability transition pore (mPTP). Here we report that the NAD+-dependent deacetylase SIRT3 deacetylates the regulatory component of the mPTP, cyclophilin D (CypD) on lysine 166, adjacent to the binding si...
Biosensor plates detect mitochondrial physiological regulators and mutations in...
Rolo, Anabela P.; Palmeira, Carlos M.; Cortopassi, Gino A.http://www.sciencedirect.com/science/article/B6W9V-4TMBPVF-7/2/3e75ce2b20adb3707a2d6c0aef2493a0
Differential alterations in mitochondrial function induced by a choline-deficie...
Teodoro, João S.; Rolo, Anabela P.; Duarte, Filipe V.; Simões, Anabela M.; Palmeira, Carlos M.http://www.sciencedirect.com/science/article/B6W8G-4T72WXD-1/2/734055ec11eadc8100fee13e06c683d5
Indirubin-3'-oxime impairs mitochondrial oxidative phosphorylation and prevents...
Varela, Ana T.; Gomes, Ana P.; Simões, Anabela M.; Teodoro, João S.; Duarte, Filipe V.; Rolo, Anabela P.; Palmeira, Carlos M.http://www.sciencedirect.com/science/article/B6WXH-4T7085D-2/2/535e45a8cc0ac06fe24206561a5ee793
Hyperglycemia decreases mitochondrial function: The regulatory role of mitochon...
Palmeira, Carlos M.; Rolo, Anabela P.; Berthiaume, Jessica; Bjork, James A.; Wallace, Kendall B.Increased generation of reactive oxygen species (ROS) is implicated in "glucose toxicity" in diabetes. However, little is known about the action of glucose on the expression of transcription factors in hepatocytes, especially those involved in mitochondrial DNA (mtDNA) replication and transcription. Since mitochondrial functional capacity is dynamically regulated, we hypothesized that stressful conditions of hy...
Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress
Rolo, Anabela P.; Palmeira, Carlos M.Hyperglycemia resulting from uncontrolled glucose regulation is widely recognized as the causal link between diabetes and diabetic complications. Four major molecular mechanisms have been implicated in hyperglycemia-induced tissue damage: activation of protein kinase C (PKC) isoforms via de novo synthesis of the lipid second messenger diacylglycerol (DAG), increased hexosamine pathway flux, increased advanced g...
Decreased ANT content in Zucker fatty rats: Relevance for altered hepatic mitoc...
Teodoro, João; Rolo, Anabela P.; Oliveira, Paulo J.; Palmeira, Carlos M.Mitochondria from Zucker fatty (ZF) rats (a model for fatty liver disease) showed a delay in the repolarization after a phosphorylative cycle and a decrease on state 3 respiration, suggesting alterations at the phosphorylative system level. The ATPase activity showed no differences between control and ZF rats, implying alterations in other components of the phosphorylative system. A pronounced depletion in the ...
Mitochondrial Bioenergetics, Diabetes, and Aging: Top-Down Analysis Using the D...
Ferreira, Fernanda M.; Moreno, António J.; Seiça, Raquel; Santos, Maria S.; Palmeira, Carlos M.In the present study we investigated the changes in the oxidative phosphorylation system of liver mitochondria, isolated from diabetic Goto-Kakizaki (GK) and Wistar (control) rats with different ages (6, 12, 26, and 52 weeks). We used a kinetic approach known as “top-down” analysis, which conceptually divides the oxidative phosphorylation system into two subsystems: one producing the protonmotive force (Δp) and...
Mitochondrially-mediated toxicity of bile acids
Palmeira, Carlos M.; Rolo, Anabela P.In the healthy hepatocyte, uptake of bile acids across the basolateral membrane and export via the canalicular export pump, are tightly coupled. Impairment of bile formation or excretion results in cholestasis, characterized by accumulation of bile acids in systemic blood and within the hepatocyte. When the concentration of bile acids exceeds the binding capacity of the binding protein located in the cytosol of...
Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mi...
Oliveira, Paulo J.; Seica, Raquel; Santos, Dario L.; Rolo, Anabela P.; Sardao, Vilma A.; Ferreira, Fernanda M. L.; Palmeira, Carlos M.; Santos, Maria S.The heart is one of the organs affected during the later stages of diabetes. Mitochondrial function has already been proposed to be affected during the course of diabetes. Nevertheless, little information is known concerning the impact of antioxidants in heart mitochondria of a milder model for diabetes, such as the Goto-Kakizaki (GK) rat, where mitochondrial function appears ameliorated. The objective of this ...
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