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Enhanced permeability transition explains the reduced calcium uptake in cardiac...
Oliveira, Paulo J.; Seiça, Raquel; Coxito, Pedro M.; Rolo, Anabela P.; Palmeira, Carlos M.; Santos, Maria S.; Moreno, António J. M.Cardiac dysfunction is associated with diabetes. It was previously shown that heart mitochondria from diabetic rats have a reduced calcium accumulation capacity. The objective of this work was to determine whether the reduction in calcium accumulation by cardiac mitochondria from diabetic rats is related to an enhanced susceptibility to induction of the mitochondrial permeability transition. Streptozotocin-indu...
Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenz...
Ferreira, Fernanda M.; Seiça, Raquel; Oliveira, Paulo J.; Coxito, Pedro M.; Moreno, António J.; Palmeira, Carlos M.; Santos, Maria S.Several studies have been carried out to evaluate the alterations in mitochondrial functions of diabetic rats. However, results are sometimes controversial, since experimental conditions diverge, including age and strain of used animals. The purpose of this study was to evaluate the metabolic modifications in liver mitochondria, both in the presence of severe (STZ-treated rats) and mild hyperglycaemia [Goto-Kak...
Inhibitory effect of carvedilol in the high-conductance state of the mitochondr...
Oliveira, Paulo J.; Coxito, Pedro M.; Rolo, Anabela P.; Santos, Dario L.; Palmeira, Carlos M.; Moreno, António J. M.The mitochondrial permeability transition is a widely studied, but poorly understood, phenomenon in mitochondrial bioenergetics. It has been recognised that this phenomenon is related to the opening of a protein pore in the inner mitochondrial membrane, and that opening of this pore is the cause of some forms of mitochondrial dysfunction. In this work, we propose that carvedilol, a multi-role cardioprotective c...
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