Supercritical fluid impregnation of a biocompatible polymer for ophthalmic drug...

• Author(s): Duarte, Ana Rita C. ; Simplicio, Ana Luísa ; Vega-González, Arlette ; Subra-Paternault, Pascale ; Coimbra, Patrícia ; Gil, M. H. ; Sousa, Hermínio C. de ; Duarte, Catarina M. M.
• Date: 2007
• Persistent ID: http://hdl.handle.net/10316/3785
• Origin: Estudo Geral - Universidade de Coimbra
• Subject(s): Supercritical fluids; Impregnation; Biocompatible polymers; Ophthalmic drug delivery
• Document Type: Article
• Language: English

Description

Supercritical fluid impregnation was tested to prepare a new ophthalmic drug delivery device. Poly(methylmethacrylate-co-ethylhexylacrylate-co-ethyleneglycoldimethacrylate), P(MMA-EHA-EGDMA) has been proposed by Mariz [M. Mariz, Preparação de uma lente intra-ocular dotada de um sistema de libertação controlada de fármaco, Master Thesis, Universidade de Coimbra, 1999] as a promising matrix to be used for intraocular delivery of anti-inflammatory drugs used in eye surgery. This matrix was successfully impregnated with flurbiprofen, a non-steroidal anti-inflammatory agent. http://www.sciencedirect.com/science/article/B6VMF-4N02J5M-1/1/ee8d7c5effb50ccf2b99656a67b77dac