Encontrados 11 documentos, a visualizar página 1 de 2
Comparison of a xenogeneic and an alloplastic material used in dental implants ...
Figueiredo, Andreia; Coimbra, Patrícia; Cabrita, António; Guerra, Fernando; Figueiredo, MargaridaTwo commercial bone grafts used in dentistry (Osteobiol Gen-Os®, a xenograft of porcine origin, and Bonelike®, a hydroxyapatite based synthetic material), in the form of granules, were characterized and evaluated in vivo regarding the intensity of the tissue inflammatory response. These biomaterials were characterized in terms of morphology, particle size distribution, porosity and pore size, specific surface a...
Designing polymeric microparticles for biomedical and industrial applications
Campos, Elisa; Branquinho, J.; Carreira, Ana S.; Carvalho, Anabela; Coimbra, Patrícia; Ferreira, P.; Gil, M. H.Nowadays, there are almost limitless applications for microparticles. Microparticles are used as components in many advanced materials and composites, in the healthcare and personal grooming industries, and in many research and development applications. This review presents an overview of recent and current studies carried out at the Particles, Polymers and Biomaterials Technology Group of the University of Coi...
Preparação e caracterização de sistemas de libertação controlada de fármacos co...
Coimbra, Patrícia Manuela AlmeidaThe main purpose of this work is the preparation and development of several controlled drug delivery systems built with natural polymers and suitable for different applications, like for colon-specific drug delivery or for the localized and prolonged delivery of drugs. With this objective, three potential controlled drug delivery systems, based on natural polymers, were prepared and characterized. In the first ...
Solubility of Irgacure® 2959 photoinitiator in supercritical carbon dioxide: Ex...
Coimbra, Patrícia; Fernandes, Daniel; Ferreira, Paula; Gil, Maria H.; Sousa, Hermínio C. deCIBA photoinitiator Irgacure® 2959 is a highly efficient radical photoinitiator for UV curing systems. Furthermore, and due to its proven low cellular toxicity, this photoinitiator can also be employed in the photopolymerization of polymers and copolymers intended for biomedical and tissue engineering applications, not only in conventional pharmaceutically accepted liquid solvents, but also in supercritical CO2...
Solubility of Diflunisal in Supercritical Carbon Dioxide
Coimbra, Patrícia; Fernandes, Daniel; Gil, Maria H.; Sousa, Hermínio C. deThe solubility of diflunisal, a nonsteroidal anti-inflammatory drug (NSAID), in supercritical carbon dioxide (scCO2) was measured at (308.2, 318.2, and 328.2) K and in the pressure range from (9.0 up to 25.0) MPa. Results were obtained using a static analytical method. Experimental solubility was found to be between 0.54·10−6 and 8.07·10−6 (in terms of diflunisal mole fraction). Experimental data were satisfact...
Preparation and characterization of flurbiprofen-loaded poly(3-hydroxybutyrate-...
Coimbra, Patrícia A.; Sousa, Hermínio C. de; Gil, Maria H.Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microspheres containing flurbiprofen were prepared by an oil-in-water emulsion solvent evaporation method, in order to develop a particulate drug delivery system for localized administration. A response surface method (RSM) using a central composite design was employed to evaluate the effect of the poly(vinyl alcohol) (PVA) (%, w/v) concentration in the aqueou...
Supercritical fluid impregnation of a biocompatible polymer for ophthalmic drug...
Duarte, Ana Rita C.; Simplicio, Ana Luísa; Vega-González, Arlette; Subra-Paternault, Pascale; Coimbra, Patrícia; Gil, M. H.; Sousa, Hermínio C. deSupercritical fluid impregnation was tested to prepare a new ophthalmic drug delivery device. Poly(methylmethacrylate-co-ethylhexylacrylate-co-ethyleneglycoldimethacrylate), P(MMA-EHA-EGDMA) has been proposed by Mariz [M. Mariz, Preparação de uma lente intra-ocular dotada de um sistema de libertação controlada de fármaco, Master Thesis, Universidade de Coimbra, 1999] as a promising matrix to be used for intraoc...
Sorption and diffusion of dense carbon dioxide in a biocompatible polymer
Duarte, Ana Rita C.; Martins, Carlos; Coimbra, Patrícia; Gil, Maria H. M.; Sousa, Hermínio C. de; Duarte, Catarina M. M.Mass sorption and diffusion coefficients in one acrylate biocompatible copolymer contacted with supercritical (sc) carbon dioxide are reported. Equilibrium solubility of dense carbon dioxide in poly(methylmethacrylate-co-ethylhexylacrylate-co-ethyleneglycoldimethacrylate) (P(MMA-EHA-EGDMA)) was studied by a gravimetric method in a temperature range from 308 to 323 K and a pressure range from 10.0 to 20.0 MPa. T...
Experimental Determination and Correlation of Artemisinin's Solubility in Super...
Coimbra, Patrícia; Blanco, Miguel R.; Silva, Hélio S. R. Costa; Gil, Maria H.; Sousa, Hermínio C. deThe measurement and correlation of the experimental solubility of the antimalarial artemisinin (Artemisia annua L.) in supercritical carbon dioxide is reported. Results were obtained using a static analytical method at 308.2, 318.2, and 328.2 K, and in a pressure range from 10.0 up to 25.0 MPa. Solubility experimental data were correlated with three density-based models (Chrastil, Bartle, and Méndez-Santiago−Te...
Solubility of Flurbiprofen in Supercritical Carbon Dioxide
Duarte, Ana Rita C.; Coimbra, Patrícia; Sousa, Hermínio C. de; Duarte, Catarina M. M.Equilibrium solubility of flurbiprofen, a nonsteroidal antiinflammatory agent, in supercritical carbon dioxide was measured by a static analytical method in the pressure range from (8.0 to 25.0) MPa, at temperatures of (303.0, 313.0, and 323.0) K. The cosolvent effect of ethanol in the solubility of the bioactive compound in supercritical carbon dioxide was investigated at 18 MPa and 313 K. The results obtained...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||