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Supercritical fluid impregnation of a biocompatible polymer for ophthalmic drug...
Duarte, Ana Rita C.; Simplicio, Ana Luísa; Vega-González, Arlette; Subra-Paternault, Pascale; Coimbra, Patrícia; Gil, M. H.; Sousa, Hermínio C. deSupercritical fluid impregnation was tested to prepare a new ophthalmic drug delivery device. Poly(methylmethacrylate-co-ethylhexylacrylate-co-ethyleneglycoldimethacrylate), P(MMA-EHA-EGDMA) has been proposed by Mariz [M. Mariz, Preparação de uma lente intra-ocular dotada de um sistema de libertação controlada de fármaco, Master Thesis, Universidade de Coimbra, 1999] as a promising matrix to be used for intraoc...
Preparation of acetazolamide composite microparticles by supercritical antisolv...
Duarte, Ana Rita C.; Roy, C.; Gonzalez, A. V.; Duarte, Catarina M. M.; Subra-Paternault, PascaleThe possibility of preparation of ophthalmic drug delivery systems using compressed anti-solvent technology was evaluated. and RL 100 were used as drug carriers, acetazolamide was the model drug processed. Compressed anti-solvent experiments were carried out as a semi-continuous or a batch operation from a liquid solution of polymer(s) + solute dissolved in acetone. Both techniques allowed the recovery of comp...
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