Encontrados 43 documentos, a visualizar página 1 de 5
Supercritical fluid processing of natural based polymers doped with ionic liquids
Martins, M.; Craveiro, R.; Paiva, A.; Duarte, Ana Rita C.; Reis, R. L.Some approaches have been developed in our group to investigate the role of ionic liquids as process and property modifiers of natural-based polymers. In our previous work, we proposed the use of ionic liquids as plasticizing agents for the creation of porous structures from a semi-crystalline natural-based polymer. The current work intended to complement the previous studies, evaluating the ability of ionic li...
Unleashing the potential of supercritical fluids for polymer processing in tiss...
Duarte, Ana Rita C.; Santo, Vitor E.; Alves, A.; Silva, S. S.; Moreira-Silva, Joana; Silva, Tiago H.; Marques, A. P.; Gomes, Manuela E.; Sousa, R. A.One of the major scientific challenges that tissue engineering and regenerative medicine (TERM) faces to move from benchtop to bedside regards biomaterials development, despite the latest advances in polymer processing technologies. A variety of scaffolds processing techniques have been developed and include solvent casting and particles leaching, compression molding and particle leaching, thermally induced pha...
Alternative methodology for chitin/hydroxyapatite composites using ionic liquid...
Silva, S. S.; Duarte, Ana Rita C.; Oliveira, Joaquim M.; Mano, J. F.; Reis, R. L.An alternative, green method was used to develop chitin-based biocomposite (ChHA) materials by an integrated strategy using ionic liquids, supercritical fluid drying, and salt leaching. ChHA matrices were produced by dissolving chitin in 1-butyl-methylimidazolium acetate along with salt and/or hydroxyapatite particles and then subsequent drying. The ChHA composite formed had a heterogeneous porous microstructur...
Nanostructured hollow tubes based on chitosan and alginate multilayers
Silva, Joana M.; Duarte, Ana Rita C.; Custódio, Catarina; Sher, Praveen; Neto, Ana I.; Pinho, A. C. Marques de; Fonseca, Jaime C.; Reis, R. L.The design and production of structures with nanometer-sized polymer fi lms based on layer-by-layer (LbL) are of particular interest for tissue engineering since they allow the precise control of physical and biochemical cues of implantable devices. In this work, a method is developed for the preparation of nanostructured hollow multilayers tubes combining LbL and template leaching. The aim is to produce hollo...
Porous hydrogels from shark skin collagen crosslinked under dense carbon dioxid...
Silva, S. P.; Moreira-Silva, J.; Silva, Tiago H.; Perez-Martin, R. I.; Sotelo, C. G.; Mano, J. F.; Duarte, Ana Rita C.; Reis, R. L.The possibility to fabricate marine collagen porous structures crosslinked with genipin under high pressure carbon dioxide is investigated. Collagen from shark skin is used to prepare prescaffolds by freeze-drying. The poor stability of the structures and low mechanical properties require crosslinking of the structures. Under dense CO2 atmosphere, crosslinking of collagen pre-scaffolds is allowed for 16 h. Addi...
Tailor made degradable ureteral stents from natural origin polysaccharides
Barros, Alexandre A.; Duarte, Ana Rita C.; Pires, R. A.; Lima, Estêvão Augusto Rodrigues de; Mano, J. F.; Reis, R. L.A urinary stent is defined as a thin tube, which is inserted in the ureter to prevent or treat the obstruction of urine flow from the kidney. Silicone, latex, polyvinylchloride and polyurethanes are the most widely used materials for the preparation of stents. Nonetheless, severe clinical complications may result from the use of these materials such as fracture, encrustation and infection. In some of the cases,...
Platelets lysate-based membranes for periodontal ligament regeneration
Babo, P. S.; Santo, Vítor E.; Duarte, Ana Rita C.; Gomes, Manuela E.; Reis, R. L.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; The periodontal ligament (PDL) is a group of specialized connective tissue fibers that attach a tooth to the alveolar bone where it is deployed. These fibers help the tooth withstand the substantial compressive forces which occur during chewing and remain embedded in the bone. Periodontitis is a prevalent infection...
Designing novel starch/cellulose acetate structures for biomedical applications
Martins, M.; Silva, S. S.; Duarte, Ana Rita C.; Reis, R. L.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; Starch-based blends present an enormous potential to be widely used in the biomedical area, because they are totally biodegradable, inexpensive, available in large quantities. However, natural-based polymers have great limitations in processability particularly due to their usually high crystallinity which limits t...
Nanostructured hollow tubes based on chitosan and alginate multilayers
Silva, Joana M.; Duarte, Ana Rita C.; Custódio, Catarina; Sher, Praveen; Neto, Ana I.; Reis, R. L.; Mano, J. F.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; The design and production of structures with nanometer-sized polymer films based on layer-by-layer (LbL) are of particular interest for tissue engineering since they allow the precise control of physical and biochemical cues, as well as the recreation of the natural complexity of ECM. In this work, we develop a met...
Marine sponges as natural scaffolds : decellularization by supercritical fluid ...
Duarte, Ana Rita C.; Silva, Joana M.; Silva, Tiago H.; Osinga, R.; Ilan, M.; Marques, A. P.; Mano, J. F.; Reis, R. L.Marine sponges possess remarkable structures, with highly interconnected pores, making them excellent candidates as nature made scaffolds with potential use in tissue engineering strategies. In addition they also exhibit interesting high swelling degree and a skeleton composed mainly of collagen fibres, in some species with embedded siliceous or carbonate spicules. In the present study, several marine sponges (...
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