Document details

Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice

Author(s): Jr., A. S. Aguiar cv logo 1 ; Moreira, E. L. G. cv logo 2 ; Hoeller, A. A. cv logo 3 ; Oliveira, P. A. cv logo 4 ; Córdova, F. M. cv logo 5 ; Glaser, V. cv logo 6 ; Walz, R. cv logo 7 ; Cunha, R. A. cv logo 8 ; Leal, R. B. cv logo 9 ; Latini, A. cv logo 10 ; Prediger, R. D. S. cv logo 11

Date: 2013

Persistent ID: http://hdl.handle.net/10316/27237

Origin: Estudo Geral - Universidade de Coimbra

Subject(s): DARPP-32; dyskinesia; exercise; l-DOPA; Parkinson’s disease; 6-OHDA


Description
l-DOPA alleviates the motor symptoms of Parkinson’s disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this l-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with l-DOPA/benserazide (25/12.5 mg/kg, i.p.) without and with possibility to exercise (running wheel) during 2 weeks. Exercise drastically prevented the development of LID, and its associated aberrant striatal signaling, namely the hyperphosphorylation of dopamine and cAMP-regulated phosphoprotein 32 kDa protein and c-Fos expression. Our results indicate that exercise can partially prevent the development of LID through the normalization of striatopallidal dopaminergic signaling.
Document Type Article
Language Portuguese
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